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Selenium is dependent on glutathione. For more research on glutathione and its relationship to the heart and the health and function of the heart
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| Source: Acta Paediatr Scand 1990 Dec;79(12):1259-62 |
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Potentially life-threatening cardiac dysrhythmia in a child with selenium deficiency and phenylketonuria.
Greeves LG, Carson DJ, Craig BG, McMaster D.
Department of Child Health and Medicine, Royal Belfast Hospital for Sick Children, Queen's University, Belfast, N. Ireland.
Selenium deficiency is a frequent finding in children with phenylketonuria (PKU) receiving dietary treatment. We report the occurrence of episodic ventricular tachycardia in a 9-month-old infant with PKU. Serum selenium (Se), 0.13 mumol/l (normal range 0.28-1.12 mumol/l, mean +/- 2 SD), and whole blood
glutathione peroxidase (GSHPX), 16 U/g Hb (normal range 19.5-34.3 U/g Hb, mean +/- 2 SD), were low. Auscultation of cardiac rhythm is recommended during the routine follow-up of young children with PKU.
Se deficiency should be considered in the aetiology of a dysrhythmia and corrected with Se supplementation.
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