Glutathione. What is glutathione, how is glutathione made and how to safely increase glutathione levels answered on the Web Site. Glutathione used to treat toxicity, acne, cancer, HIV, allergies, Alzheimer's disease, cystic fibrosis, diabetes, hepatitis, liver dysfunction and more.

Glutathione

What is Glutathione
Glutathione is a small molecule made up of three amino acids, which exists in almost every cell of the body. However, glutathione, must be generated within the cell from its precursors before it can work effectively in the body.

The presence of glutathione is required to maintain the normal function of the immune system. It is known to play a critical role in the multiplication of lymphocytes (the cells that mediate specific immunity) which occurs in the development of an effective immune response.

Furthermore, the cells of the immune system produce many oxiradicals as a result of their normal functioning, resulting in a need for higher concentrations of antioxidants than most cells. Glutathione plays a crucial role in fulfilling this requirement.

How to Make Glutathione Naturally Within the Body

There are several ways a body can manufacture glutathione. It is true it takes 3 amino acids for the body to manufacture glutathione but our bodies can take food, turn the foods into the substance to manufacture the 3 needed amino acids needed to manufacture glutathione. This is also the natural method for a body to create glutathione.

As an example, asparagus and watermelon will make glutathione. 

With all of the breaking news regarding glutathione as an antioxidant as well as part of the reason for the development of autism, many supplements are suddenly jumping on the glutathione bandwagon.

Glutathione is not new to this Web Site. We have been recommending glutathione for the past 10 years to assist individuals to taper off psychotropic medications.

One thing that has been overlooked by many still is the role of glutathione within the liver as well as the role of glutathione transporting a toxin to the liver. There is considerable more to glutathione than having it in the cells.

The whey proteins mentioned on this site do make intracellular glutathione. However, like most other things in life, not all things are equal.

When you need intracellular glutathione quickly, the best method and safest method is with a whey protein. We have reviewed the top selling whey proteins. One whey protein stands so far above all others it is amazing.

We recommend the Renew Pro over the Immune Pro. Reason: We have found the Immune Pro is actually a little too strong and the taste is bland. Compliance with the Immune Pro is no where as high as with the Renew Pro.

When you want and need intracellular glutathione, nothing compares.

You can purchase the Renew Pro from TRB Health at the best price. TRB Health manufactures nutritional products used primarily for drug detoxification and drug withdrawal by medical doctors and psychiatrist. RenewPro is one product used when a patient has anxiety, fatigue or depression. If you are not taking medication the results are even more staggering. If by chance you are taking any addictive medication or drug you should feel the positive difference rather quickly as well.

Increasing intracellular levels of glutathione is critical with drug withdrawal and it is vitally important that any supplement not cause a drug/supplement interaction. This is also why we recommend RenewPro.

Additional Glutathione Information and Clinical Trials

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Patulin-induced genotoxicity and modulation of glutathione in HepG2 cells.

Zhou SM, Jiang LP, Geng CY, Cao J, Zhong LF.

Toxicon. 2009 Feb 4. [Epub ahead of print]

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Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells.

Nam KS, Shon YH.

BMB Rep. 2009 May 31;42(5):277-80.

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Antioxidant responses of chickpea plants subjected to boron toxicity.

Ardıc M, Sekmen AH, Tokur S, Ozdemir F, Turkan I.

Plant Biol (Stuttg). 2009 May 1;11(3):328-338. Epub 2009 Jan 6.

PMID: 19470104 [PubMed - as supplied by publisher]

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Chemopreventive efficacy of pronyl-lysine on lipid peroxidation and antioxidant status in rat colon carcinogenesis.

Selvam JP, Aranganathan S, Gopalan R, Nalini N.

Fundam Clin Pharmacol. 2009 Mar 12. [Epub ahead of print]

PMID: 19469802 [PubMed - as supplied by publisher]

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Glutathione s-transferase polymorphisms in breast cancers of thai patients.

Pongtheerat T, Treetrisool M, Purisa W.

Asian Pac J Cancer Prev. 2009 Jan-Mar;10(1):127-32.

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Kinetic Binding Analysis of Aptamers Targeting HIV-1 Proteins by a Combination of a Microbalance Array and Mass Spectrometry (MAMS).

Gronewold TM, Baumgartner A, Hierer J, Sierra S, Blind M, Schäfer F, Blümer J, Tillmann T, Kiwitz A, Kaiser R, Zabe-Kühn M, Quandt E, Famulok M.

J Proteome Res. 2009 May 27. [Epub ahead of print]

PMID: 19469583 [PubMed - as supplied by publisher]

A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine.

Jenkinson C, Jenkins RE, Maggs JL, Kitteringham NR, Aleksic M, Park BK, Naisbitt DJ.

Chem Res Toxicol. 2009 May 26. [Epub ahead of print]

PMID: 19469519 [PubMed - as supplied by publisher]

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The protective effect of alpha lipoic acid against traumatic brain injury in rats.

Toklu HZ, Hakan T, Biber N, Solakoğlu S, Oğunc AV, Sener G.

Free Radic Res. 2009 May 25:1-10. [Epub ahead of print]

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Prevention of nicotine and streptozotocin treatment induced circulatory oxidative stress by bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione in diabetic rats.

Reddy BV, Sundari JS, Balamurugan E, Menon VP.

Mol Cell Biochem. 2009 May 26. [Epub ahead of print]

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Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms.

Grotto D, de Castro MM, Barcelos GR, Garcia SC, Barbosa F Jr.

Arch Toxicol. 2009 May 26. [Epub ahead of print]

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Effects of perfluorooctanoate and perfluorooctane sulfonate exposure on hepatoma Hep G2 cells.

Hu XZ, Hu DC.

Arch Toxicol. 2009 May 27. [Epub ahead of print]

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MER1, a novel organic arsenic derivative, has potent PML-RARalpha- independent cytotoxic activity against leukemia cells.

Golemovic M, Quintás-Cardama A, Manshouri T, Orsolic N, Duzkale H, Johansen M, Freireich EJ, Kantarjian H, Zingaro RA, Verstovsek S.

Invest New Drugs. 2009 May 26. [Epub ahead of print]

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Polyunsaturated fatty acid and S-adenosylmethionine supplementation in predementia syndromes and Alzheimer's disease: a review.

Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Di Palo A, Imbimbo BP, Vendemiale G, Capurso A, Solfrizzi V.

ScientificWorldJournal. 2009 May 22;9:373-89.

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Do smoking and polymorphisms in xenobiotic metabolizing enzymes affect the histological stage and grade of bladder tumors?

Ouerhani S, Rouissi K, Marrakchi R, Riadh Ben Slama M, Sfaxi M, Ayed M, Chebil M, Elgaaied A.

Bull Cancer. 2009 May;96(5):E23-9.

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Angiotensin-converting enzyme inhibition and angiotensin AT(1)-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity.

Ibrahim MA, Ashour OM, Ibrahim YF, El-Bitar HI, Gomaa W, Abdel-Rahim SR.

Pharmacol Res. 2009 May 22. [Epub ahead of print]

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Attenuating effect of taurine on lipopolysaccharide-induced acute lung injury in hamsters.

Bhavsar TM, Cantor JO, Patel SN, Lau-Cam CA.

Pharmacol Res. 2009 May 22. [Epub ahead of print]

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N,N-Diethyldithiocarbamate promotes oxidative stress prior to myelin structural changes and increases myelin copper content.

Viquez OM, Lai B, Ahn JH, Does MD, Valentine HL, Valentine WM.

Toxicol Appl Pharmacol. 2009 May 22. [Epub ahead of print]

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Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways.

Menschikowski M, Hagelgans A, Eisenhofer G, Siegert G.

Exp Cell Res. 2009 May 22. [Epub ahead of print]

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Structural, functional and unfolding characteristics of Glutathione S-transferase of Plasmodium vivax.

Tripathi T, Na BK, Sohn WM, Becker K, Bhakuni V.

Arch Biochem Biophys. 2009 May 22. [Epub ahead of print]

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Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death.

Fallarini S, Miglio G, Paoletti T, Minassi A, Amoruso A, Bardelli C, Brunelleschi S, Lombardi G.

Br J Pharmacol. 2009 May 20. [Epub ahead of print]

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Antioxidant and redox status after maximal aerobic exercise at high altitude in acclimatized lowlanders and native highlanders.

Sinha S, Ray US, Saha M, Singh SN, Tomar OS.

Eur J Appl Physiol. 2009 May 24. [Epub ahead of print]

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Dichotomic actions of glutamine in host versus tumour: an emerging concept.

Belabed L, Darmon P, Pichard C.

Curr Opin Clin Nutr Metab Care. 2009 May 21. [Epub ahead of print]

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d -Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis.

Rabi T, Bishayee A.

J Carcinog. 2009;8:9.

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Antioxidant Enzyme Activity and Coronary Heart Disease: Meta-analyses of Observational Studies.

Flores-Mateo G, Carrillo-Santisteve P, Elosua R, Guallar E, Marrugat J, Bleys J, Covas MI.

Am J Epidemiol. 2009 May 22. [Epub ahead of print]

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Weight loss increases antioxidant mRNA levels in skeletal muscle but not erythrocyte antioxidant activity in beef cows.

Brennan KM, Terry EN, Michal JJ, Kincaid RL, Johnson KA.

J Anim Sci. 2009 May 22. [Epub ahead of print]

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Pyruvate prevents aging of mouse oocytes.

Liu N, Wu YG, Lan GC, Sui HS, Ge L, Wang JZ, Liu Y, Qiao TW, Tan J.

Reproduction. 2009 May 22. [Epub ahead of print]

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Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer.

Arsova-Sarafinovska Z, Eken A, Matevska N, Erdem O, Sayal A, Savaser A, Banev S, Petrovski D, Dzikova S, Georgiev V, Sikole A, Ozgök Y, Suturkova L, Dimovski AJ, Aydin A.

Clin Biochem. 2009 May 21. [Epub ahead of print]

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Hao W, Wu XQ, Xu RT.

Brain Res. 2009 May 21. [Epub ahead of print]

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An electrochemical sensing strategy for ultrasensitive detection of glutathione by using two gold electrodes and two complementary oligonucleotides.

Miao P, Liu L, Nie Y, Li G.

Biosens Bioelectron. 2009 May 3. [Epub ahead of print]

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Arsenic induces telomerase expression and maintains telomere length in human cord blood cells.

Ferrario D, Collotta A, Carfi M, Bowe G, Vahter M, Hartung T, Gribaldo L.

Toxicology. 2009 Jun 16;260(1-3):132-41. Epub 2009 Apr 9.

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Modification of urinary N7-methylguanine excretion in smokers by glutathione-S-transferase M1 polymorphism.

Lin IH, Chao MR, Hu CW, Ho ML, Huang JY, Lee HS, Chen CC, Wong RH.

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Tiwari V, Kuhad A, Bishnoi M, Chopra K.

Pharmacol Biochem Behav. 2009 May 21. [Epub ahead of print]

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Antioxidant status in patients with osteoporosis: A controlled study.

Sendur OF, Turan Y, Tastaban E, Serter M.

Joint Bone Spine. 2009 May 20. [Epub ahead of print]

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Messaoudi I, Hammouda F, El Heni J, Baati T, Saïd K, Kerkeni A.

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Rao BN, Satish Rao BS, Aithal BK, Kumar MR.

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Rongzhu L, Suhua W, Guangwei X, Chunlan R, Fangan H, Suxian C, Zhengxian Z, Qiuwei Z, Aschner M.

Neurochem Int. 2009 May 20. [Epub ahead of print]

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A novel role of catalase in detoxification of peroxynitrite in S. cerevisiae.

Sahoo R, Bhattacharjee A, Majumdar U, Sinha Ray S, Dutta T, Ghosh S.

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Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats.

Babu CS, Ramanathan M.

Pharmacol Biochem Behav. 2009 May;92(3):424-32. Epub 2009 Jan 23.

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Pollicita M, Muscoli C, Sgura A, Biasin A, Granato T, Masuelli L, Mollace V, Tanzarella C, Del Duca C, Rodino P, Perno CF, Aquaro S.

BMC Neurosci. 2009 May 22;10(1):51. [Epub ahead of print]

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[Action of a nitric oxide donor dinitrosyl complex of iron with glutathione on the circulation in rats and monkeys.]

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Kardiologiia. 2009;49(5):53-60. Russian.

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[No authors listed]

Kardiologiia. 2009;49(4):14-8. Russian.

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Inactivation of genes encoding superoxide dismutase modifies yeast response to S-nitrosoglutathione-induced stress.

Lushchak OV, Nykorak NZ, Ohdate T, Inoue Y, Lushchak VI.

Biochemistry (Mosc). 2009 Apr;74(4):445-51.

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Reszka KJ, McGraw DW, Britigan BE.

Chem Res Toxicol. 2009 May 22. [Epub ahead of print]

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Jakovljevic V, Popovic M, Raskovic A, Sabo A, Horvat O, Mitic R, Vasic R.

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Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Mar;40(2):203-7. Chinese.

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Yu DH, Bao YM, An LJ, Yang M.

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Oksuz H, Bulbuloglu E, Senoglu N, Ciralik H, Yuzbasioglu MF, Kilinc M, Dogan Z, Goksu M, Yildiz H, Ozkan OV, Atli Y.

Ren Fail. 2009;31(4):297-302.

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Uz E, Karatas OF, Mete E, Bayrak R, Bayrak O, Atmaca AF, Atis O, Yildirim ME, Akcay A.

Ren Fail. 2009;31(4):251-60.

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Early transcriptional deregulation of hepatic mitochondrial biogenesis and its consequent effects on murine cholestatic liver injury.

Tiao MM, Lin TK, Liou CW, Wang PW, Chen JB, Kuo FY, Huang CC, Chou YM, Chuang JH.

Apoptosis. 2009 May 22. [Epub ahead of print]

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Do heavy metals and metalloids influence the detoxification of organic xenobiotics in plants?

Schröder P, Lyubenova L, Huber C.

Environ Sci Pollut Res Int. 2009 May 22. [Epub ahead of print]

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Scuba diving increases erythrocyte and plasma antioxidant defenses and spares NO without oxidative damage.

Sureda A, Ferrer MD, Batle JM, Tauler P, Tur JA, Pons A.

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Rifampicin-Activated Human PXR and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity.

Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ.

Drug Metab Dispos. 2009 May 21. [Epub ahead of print]

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Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma.

Aceto N, Bertino P, Barbone D, Tassi G, Manzo L, Porta C, Mutti L, Gaudino G.

Eur Respir J. 2009 May 21. [Epub ahead of print]

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Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver.

Leipnitz G, Seminotti B, Fernandes CG, Amaral AU, Beskow AP, da Silva Lde B, Zanatta A, Ribeiro CA, Vargas CR, Wajner M.

Int J Dev Neurosci. 2009 Jun;27(4):351-6. Epub 2009 Mar 13.

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Richardson KL, Gold Bouchot G, Schlenk D.

Comp Biochem Physiol C Toxicol Pharmacol. 2009 May 19. [Epub ahead of print]

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Functional properties of the Ustilago maydis alternative oxidase under oxidative stress conditions.

Sierra-Campos E, Velázquez I, Matuz-Mares D, Villavicencio-Queijeiro A, Pardo JP.

Mitochondrion. 2009 Apr;9(2):96-102. Epub 2009 Jan 17.

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Human G-CSF synthesis using stress-responsive bacterial proteins.

Song JA, Han KY, Park JS, Seo HS, Ahn KY, Lee J.

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Tartari S, D'Alessandro G, Babetto E, Rizzardini M, Conforti L, Cantoni L.

FEBS J. 2009 May;276(10):2861-74.

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Antioxidant responses to acute ozone challenge in the healthy human airway.

Behndig AF, Blomberg A, Helleday R, Duggan ST, Kelly FJ, Mudway IS.

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Mohamad RH, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM.

J Med Food. 2009 Apr;12(2):394-402.

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Reddy VD, Padmavathi P, Varadacharyulu NCh.

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Choi JH, Choi CY, Lee KJ, Hwang YP, Chung YC, Jeong HG.

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Srp Arh Celok Lek. 2009 Mar-Apr;137(3-4):146-51. Serbian.

Characteristics of antioxidant system in dog semen.

Strzezek R, Koziorowska-Gilun M, Kowalówka M, Strzezek J.

Pol J Vet Sci. 2009;12(1):55-60.

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The effects of feeding with different levels of zinc and chromium on plasma thiobarbituric acid reactive substances and antioxidant enzymes in rats.

Esen Gursel F, Tekeli SK.

Pol J Vet Sci. 2009;12(1):35-9.

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Yu M, Mu R, Lü M, Li A, Guo N.

Sheng Wu Gong Cheng Xue Bao. 2009 Feb;25(2):257-62. Chinese.

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Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC).

Li M, Chiu JF, Kelsen A, Lu SC, Fukagawa NK.

J Cell Biochem. 2009 May 20. [Epub ahead of print]

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Selenium and Glutathione Peroxidase Status in Adult Egyptian Patients with Acute Myeloid Leukemia.

Asfour IA, El-Kholy NM, Ayoub MS, Ahmed MB, Bakarman AA.

Biol Trace Elem Res. 2009 May 21. [Epub ahead of print]

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Enhancement of the activity and pH-performance of chitosanase from Bacillus cereus strains by DNA shuffling.

Park YM, Ghim SY.

Biotechnol Lett. 2009 May 21. [Epub ahead of print]

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The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.

Harish Kumar G, Vidya Priyadarsini R, Vinothini G, Vidjaya Letchoumy P, Nagini S.

Invest New Drugs. 2009 May 21. [Epub ahead of print]

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Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats.

Ohta T, Masutomi N, Tsutsui N, Sakairi T, Mitchell M, Milburn MV, Ryals JA, Beebe KD, Guo L.

Toxicol Pathol. 2009;37(4):521-35.

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Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity.

Fernández A, Llacuna L, Fernández-Checa JC, Colell A.

J Neurosci. 2009 May 20;29(20):6394-405.

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Analysis of the Association of the Human Cytomegalovirus DNA Polymerase Subunit UL44 with the Viral DNA Replication Factor UL84.

Strang BL, Sinigalia E, Silva LA, Coen DM, Loregian A.

J Virol. 2009 May 20. [Epub ahead of print]

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Effect of combined treatment with aflatoxin B1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens.

Pál L, Dublecz K, Weber M, Balogh K, Erdélyi M, Szigeti G, Mézes M.

Acta Vet Hung. 2009 Mar;57(1):75-84.

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Effects of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) on alcohol abuse.

Shati AA, Elsaid FG.

Food Chem Toxicol. 2009 May 18. [Epub ahead of print]

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Caffeic acid phenethyl ester prevents ovary ischemia/reperfusion injury in rabbits.

Kart A, Cigremis Y, Ozen H, Dogan O.

Food Chem Toxicol. 2009 May 18. [Epub ahead of print]

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In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats.

Grover P, Singh SP, Prabhakar PV, Reddy UA, Balasubramanyam A, Mahboob M, Rahman MF, Misra S.

Food Chem Toxicol. 2009 May 18. [Epub ahead of print]

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Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue.

Dursun H, Bilici M, Albayrak F, Ozturk C, Saglam MB, Alp HH, Suleyman H.

BMC Gastroenterol. 2009 May 20;9(1):36. [Epub ahead of print]

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Sulfasalazine inhibits the growth of primary brain tumors independent of Nuclear factor-kappaB.

Chung WJ, Sontheimer H.

J Neurochem. 2009 Apr 29. [Epub ahead of print]

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The Molecular Chaperone Hsc70 Interacts with the Vesicular Monoamine Transporter-2.

Requena DF, Parra LA, Baust TB, Quiroz M, Leak RK, Garcia-Olivares J, Torres GE.

J Neurochem. 2009 Apr 30. [Epub ahead of print]

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p75NTR-dependent Modulation of Cellular Handling of Reactive Oxygen Species.

Mi Z, Rogers DA, Mirnics ZK, Schor NF.

J Neurochem. 2009 Apr 30. [Epub ahead of print]

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Dissecting the pleiotropic consequences of a quantitative trait nucleotide.

Kim HS, Huh J, Fay JC.

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Modulation of Phase II Enzymes by Sulforaphane: Implications for Its Cardioprotective Potential.

Angeloni C, Leoncini E, Malaguti M, Angelini S, Hrelia P, Hrelia S.

J Agric Food Chem. 2009 May 20. [Epub ahead of print]

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Differential response of antioxidative defense system of Anabaena doliolum under arsenite and arsenate stress.

Srivastava AK, Bhargava P, Thapar R, Rai LC.

J Basic Microbiol. 2009 May 19. [Epub ahead of print]

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Mishra PK, Khan S, Bhargava A, Panwar H, Banerjee S, Jain SK, Maudar KK.

Cell Biol Toxicol. 2009 May 21. [Epub ahead of print]

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The non-essential amino acid homocysteine is produced in the body with the metabolism of the amino acid methionine.

Homocysteine is usually broken down into the amino acid cysteine. Cysteine is one of the amino acids needed by the cells to make intracellular glutathione. If your body does not convert homocysteine to cysteine the intracellular glutathione conversion will not take place.

The rapid conversion of homocysteine is critical. If conversion takes place too slow, homocysteine will accumulate in the body and damage cell membranes, damage blood vessels, increase the risk of cardiovascular disease, and atherosclerosis.

Rapid conversion of homocysteine requires an individual to have adequate amount of vitamin B6, B12, and folate. Over 50% of the population in the world has a genetic defect in the pathway needed to metabolize B6, B12, and folate.

The site mentioned above, www.trbhealth.com also has a sublingual vitamin B6, B12 and folate.

Metabolism of homocysteine (sulphur-containing amino acid) is accomplished in the remethylation cycle where vitamin B12 and folic acid are essential coenzymes and degraded to methionine or through transsulfuration, which use as cofactors folate, vitamin B6 and vitamin B12 and is degraded to cystathionine.

The physician can check for hyperhomocysteine (higher than normal amount of homocysteine) with a blood test. Many medication side effects, physiological symptomology and other body and mental symptoms can be eliminated with treatment with vitamins B6, B12 and folate.

Age is a factor of B6, B12 and folate metabolism despite an individuals DNA. With age, the enzyme needed to metabolize B6, B12 and folate will be depleted and the need to supplement through nutrition increases proportionally.

High levels of homocysteine will be toxic on cells that line the arteries which will make the blood prone to clotting and promote bad cholesterol (LDL) which will be deposited as plaque in blood vessels.

Cysteine helps to detoxify toxins and protect the body from radiation damage. Cysteine as well as selenium work hand in hand with vitamin E. Cysteine also needs selenium to be effective.

Cysteine will bind with soluble iron, chelates heavy metals, and breaks down mucus in the respiratory tract, beneficial for bronchitis, emphysema, and tuberculosis.

Of note: Cysteine as a stand-alone supplement should be avoided due to toxicity.

Glutathione - Recap

Cysteine is the pre-cursor to glutathione, the body’s natural antioxidant. Glutathione regulates the antioxidant redox state, and allows the body to recycle its store of antioxidants including: vitamin A, C, E and Co-enzyme Q10.

Free cysteine is unstable and is readily oxidized producing compounds that could have harmful effects. Glutathione cannot be absorbed by cells and so must be re-synthesized intracellularly.

Glutathione is the antioxidant that is prevalent in every cell in the human body. Glutathione is primarily synthesized in the liver where it is abundantly present.

80-90% of the blood that leaves the stomach and intestines passes through the liver. The blood carries important nutrients to the liver where they are metabolized into substances vital to life. In the same way, exogenous toxic substances reach the liver where they are either activated or transformed into less toxic derivatives. Glutathione plays a crucial role in the liver’s biotransformation system.

The liver biotransformation system comprises important functions:

  1. Filtering alcohol and other toxic substances from the blood.
     
  2. Processing drugs and medications absorbed through the digestive system, enabling the body to use them effectively and ultimately dispose of them.

The liver uses glutathione to process; alcohol, caffeine, medications, nicotine as an example, to process such substances and remove them from the blood. Cysteine is the limiting factor in glutathione synthesis, ensuring an adequate supply of glutathione helps cleanse the blood of toxins and substances.

The role of glutathione and its inter-workings with alcohol and the metabolism has received the attention of scientist for years. With alcohol metabolism using the P 450 enzymes, much of the alcohol studies can be transformed into applicable knowledge with antidepressants and other medications that use the same system.

Ethanol and Glutathione

Reduced glutathione plays a critical role in the cellular detoxification processes including the metabolism of peroxides, the conjugation with electrophils and the scavenging of the free radicals. The relevance of glutathione in ethanol metabolism consists mainly in compensating for alcohol-related oxidative stress. Oxidative stress is a disturbance in the pro-oxidant/antioxidant balance (increased pro-oxidant levels), which may be achieved by either an enhancement of oxidative reactions leading to the increased formation of reactive oxygen species (ROS) or by a decrease of the antioxidant defense.

Whether you are working with alcohol or most medications, both will activate the microsomal Cytochrome P450-dependant enzyme system, especially the subclass CYP2E1, that plays an important role in the liver detoxification. With antidepressants it will usually be with the subclass CYP2D6 or the CYP2C9 pathways.

Glutathione (GSH) will be depleted within the cells and liver and also in other organs in the body due to the absorption of toxins by glutathione.

The Creation of Glutathione

Knowing the theory of glutathione is useful but without the correct application of the data it is pointless.

Increasing glutathione intracellularly can be done in only a few ways. Using a whey protein designed in such a way to present to the cells the required amino acids in the exact sequence or by nutrients and or foods.

The natural way for our body to produce intracellular glutathione is with all natural nutrients. This is also how I recommend an individual increase intracellular glutathione if possible. However, with knowing 50% of the population has the genetic makeup that gets in the way of the body's ability to create glutathione naturally from food, a whey protein may be your best answer.

Why?

Imagine you have a car that will not start because the battery is low in power. You can give the car a jumpstart and drive down the road but the chances are you will need to keep getting a jumpstart every time you wish to drive.

The above example is what is happening when you bypass the natural structure of the body.

If you were to fill the battery with water and put it on a slow charge until it was at full power you should not have to rely on a jumpstart again.

This example is what should take place within the body regarding the creation of glutathione.

Putting the correct nutrients in the body and allowing the body to use the nutrients to eventually manufacture glutathione not only gets those body parts working again but also promotes long-term health.

Your body can manufacture glutathione with the correct nutrients.

If you have been told it takes one of these whey proteins to manufacture glutathione and that is the only way to do it, someone has lied to you.

Immunotec Research, a network marketing company (Multi-level Marketing) and the manufacture of a whey protein called Immunocal has had their attorney contact me regarding statements on this Web Site about their product as well as glutathione. The attorney insisted I take the information down.

I asked the simple question: "Tell me what specific point I have made that is not true about glutathione or Immunocal and I will take it off the site immediately." The attorney could not site one example. He did not even try.

The main problem I had with Immunocal and their promotion of the product that prompted the call from their attorney were their claims.

 I discovered the patents they were basing their claims from were not the same product being sold now. Immunocal was still a whey protein but the Immunocal manufacturing procedure had changed dramatically. The entire structure of their product had changed.

Within a few months after telling the Immunotec attorney their current product is not the same product they are basing their claim from, Immunotec removed all reference of their earlier patents related to the current Immunocal being sold.

I do feel Immunocal is a good whey protein but I do want the reader to know you will need to do your own research on current Immunocal claims and a full research needs to be conducted if the information you are receiving comes from a network marketing professional that sells Immunocal. This includes any doctor that may be making outlandish claims and part of the Immunotec Network Marketing program.

If you want to purchase Immunocal, http://www.immunotec.com/JGebhardt sells it at the lowest price I can find. (This Web Site is not affiliated with Immunotec, Immunocal or this distributor)

The best whey protein product we have found for increasing intracellular glutathione is Renew Pro. It can be purchased from TRB Health site. Click here (This Web Site does not sell Renew pro)

Glutathione as a Detoxicant
Supplemental detoxicants become necessary as our environment becomes increasingly polluted. Our food and water sources are contaminated with chemicals. One of our main defenses against pollutants is glutathione, which is present in the liver in high concentrations. Glutathione acts as a detoxifying agent by combining with undesirable substances and ridding the body of them through urine and bile. It is important to note that unless the Colon, Liver and Blood are also detoxified, the benefits of Glutathione as a detoxicant may be minimized.

To Get a Little More Technical About Glutathione
"Glutathione is a ubiquitous tripeptide molecule, consisting of three amino acids joined together. These are cysteine, glutamic acid and glycine - three of the twenty two amino acids which comprise the building blocks of all known proteins. In general, the amino-end of one amino acid combines with the acid-end of another to form a peptide bond with the elimination of water. Chains of amino acids are called proteins. The sequence of amino acids and the arrangement in space of each peptide bond defines some specific structural features of all proteins and olegopeptides (few amino acids in sequence) that relate to their function."

Glutathione (Psychoneurobiology)

"Free radicals and oxyradicals have been recognized by psychoneurobiologist as playing an important role in the development and progression of many of these disorders. The brain is particularly susceptible to free radical attack because it generates more oxidative-by-products per gram of tissue than any other organ. The brain's main antioxidant is glutathione- it's importance cannot be overstated."

"Oxidative stress and glutathione are important factors in such various disorders as brain injury, neurodegenerative disease, schizophrenia, Down syndrome and other pathologies."

Disorders of the brain and nervous system that are linked to oxidative stress

Brain Injury Neurodegenerative
disease
Others
Brain injury Parkinson's disease Schizophrenia
Trauma Alzheimer's dementia Down syndrome
Stroke Multiple sclerosis (MS) Tardive dyskinesia
Ischemia Lou Gehrig's disease (ALS) Sleep deprivation
Toxicity of lead, mercury, etc. Lipofuscinosis (Batten's disease) Huntington's chorea

"Many neurological and psychiatric disease processes are characterized by high levels of oxidative stress and free radical formation, as well as abnormalities in glutathione metabolism and antioxidant defenses."

Source Dr. Gutman M.D. Glutathione GSH

Dr. Perlmutter: "Eighty to ninety percent improve dramatically. It's felt that the mechanism that allows it to work is in increasing the sensitivity to certain receptors to dopamine. Glutathione doesn't raise dopamine levels, but it allows the dopamine in the brain to be more effective. That's not a new idea in medicine. Diabetic drugs work not by increasing insulin, but by increasing the receptors to insulin. Glutathione not only increases sensitivity to dopamine, but also to serotonin, which may explain why many of our depressed PD patients have a remarkable improvement."

Increasing glutathione in the body has been proven to be essential in the treatment of disease. Antidepressants and other medications deplete the body and brain of glutathione. 

Functions of Glutathione

Enhancing the Immune System - Your bodies immune activity, involving unimpeded multiplication of lymphocytes and antibody production, requires maintenance of normal levels of glutathione inside the lymphocytes.

Antioxidant and Free Radical Scavenger - Glutathione plays a central protective role against the damaging effects of bacteria, viruses, pollutants and free radicals.

Regulator of Other Antioxidants - Without glutathione, other important antioxidants such as vitamins C and E cannot do their job adequately to protect your body against disease.

A Detoxifying Agent - Another major function of glutathione is in the detoxification of foreign chemical compounds such as carcinogens and harmful metabolites.

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