Effexor
withdrawal. Effexor
withdrawal side effects,
Effexor
withdrawal warnings,
Effexor
withdrawal precautions,
Effexor
withdrawal adverse effects, overdose, withdrawal symptoms and
Effexor
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Effexor, try giving your body what it really wants.
Effexor
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Effexor -
Alert from the F.D.A.
FDA ALERT [07/2005]: Suicidal Thoughts or Actions in
Children and Adults
Patients with depression or other mental illnesses often
think about or attempt suicide. Closely watch anyone taking antidepressants,
especially early in treatment or when the dose is changed. Patients who become
irritable or anxious, or have new or increased thoughts of suicide or other
changes in mood or behavior (or their care givers) should contact their
healthcare professional right away.
Children
Taking antidepressants may increase suicidal thoughts and actions in about 1
out of 50 people 18 years or younger. FDA has approved Zoloft for use in
children only if they have obsessive-compulsive disorder.
Adults
Several recent scientific publications report the possibility of an increased
risk for suicidal behavior in adults who are being treated with antidepressant
medications. Even before these reports became available, FDA began a complete
review of all available data to determine whether there is an increased risk of
suicidal thinking or behavior in adults being treated with antidepressant
medications. It is expected that this review will take a year or longer to
complete. In the meantime, FDA is highlighting that adults being treated with
antidepressant medication, particularly those being treated for depression,
should be watched closely for worsening of depression and for increased suicidal
thinking or behavior.
This information reflects FDA’s preliminary
analysis of data concerning this drug. FDA is considering, but has not reached a
final conclusion about, this information. FDA intends to update this sheet when
additional information or analyses become available.
Fatal venlafaxine overdose
with acinar zone 3 liver cell necrosis.
Shaw MW, Sheard JD.
Department of Cellular Pathology, University Hospital Aintree, Liverpool, UK.
We present a case of fatal venlafaxine overdose in a 34-year-old male with a
history of depression and previous suicide attempts. He presented unwell, and
his condition deteriorated with the development of rhabdomyocytolysis and renal
failure. Although treatment was provided, this was unsuccessful, and he died
within a day of his admission. A postmortem examination was performed, and the
findings included an acinar zone 3 pattern of liver cell necrosis and a very
high level of serum venlafaxine in the deceased. No other elevated drug levels
were detected. From this case, it is clear that venlafaxine overdose was the
primary cause of a fatal acinar zone 3 pattern of liver cell necrosis. As far as
we are aware, this is the first reported case of fatal acinar zone 3 liver
necrosis caused by venlafaxine overdose alone.
Serotonin syndrome and
rhabdomyolysis in venlafaxine poisoning: a case report.
Hanekamp BB, Zijlstra JG, Tulleken JE, Ligtenberg JJ, van der Werf TS, Hofstra
LS.
Intensive and Respiratory Care, Groningen University Medical Centre, Groningen,
the Netherlands. b.b.hanekamp@int.umcg.nl
Newer, more selective, antidepressant agents are increasingly being used as
first-line treatment. However, clinical experience in patients after a
deliberate overdose is limited. We present a case of venlafaxine intoxication
complicated by a late rise in creatine kinase, seizures and serotonin syndrome.
Rhabdomyolysis prolonged the hospital stay in our patient but had no other
serious consequences. Physicians should be aware of this late phenomenon in
patients with venlafaxine poisoning.
Severe rhabdomyolysis following
venlafaxine overdose.
Pascale P, Oddo M, Pacher P, Augsburger M, Liaudet L.
Division of Critical Care, Department of Internal Medicine, University Hospital,
Lausanne 1011, Switzerland.
Venlafaxine is a recently developed serotoninergic antidepressant whose reported
toxicity at overdose levels includes central nervous system depression,
seizures, and cardiovascular toxicity. The authors now present a case of
venlafaxine overdose in a young woman complicated by a rise in plasma creatine
kinase activity up to 52,600 U/L. Immediate therapy with intravenous fluids,
bicarbonate, and furosemide was administered, and there were no further
complications, notably no renal failure. This case supports the notion that
venlafaxine can induce direct skeletal muscle toxicity leading to severe
rhabdomyolysis. Therefore, clinicians should monitor muscle enzymes in patients
with venlafaxine overdose to detect the development of rhabdomyolysis at an
early stage and to initiate appropriate therapy rapidly.
Effects of paroxetine and
venlafaxine XR on heart rate variability in depression.
Davidson J, Watkins L, Owens M, Krulewicz S, Connor K, Carpenter D, Krishnan R,
Nemeroff C.
Department of Psychiatry and Behavioral Sciences, Duke University Medical
Center, Durham, NC 27710, USA.
Depressed patients may exhibit reduced heart rate variability (HRV), and
antidepressants which block norepinephrine uptake may also lower HRV. This study
compared paroxetine (PAR) and venlafaxine XR (VEN-XR) on HRV. Outpatients were
randomly assigned to double-blind treatment with PAR up to 40 mg or VEN-XR up to
225 mg daily. HRV measures of parasympathetic control consisted of change in R-R
interval during forced 10-second breaths and respiratory sinus arrhythmia (RSA)
during paced breathing. Ex vivo estimates of serotonin and norepinephrine
transporter occupancy were obtained before and after treatment, as were measures
of depression, anxiety, and resilience. Plasma drug concentrations were measured
at end point. Forty-nine patients entered treatment; 44 of whom were evaluable (n
= 22 per group). Significant within-group reductions were noted in R-R interval
variation and in RSA after VEN-XR only. Between-group analyses showed
significant group-by-time interaction, with greater reduction in R-R interval
variation and in RSA for VEN-XR compared with PAR. Improvement in resiliency
correlated significantly with norepinephrine transporter occupancy for VEN-XR.
Further comparisons of selective serotonin reuptake inhibitor and serotonin and
norepinephrine reuptake inhibitor drugs on HRV are warranted.
Effexor
withdrawal Body
Effexor
withdrawal
Dry Mouth
- The
usual amount to moisture in the mouth is noticeably less.
Effexor
withdrawal
Sweating
Increased -
A large
quantity of perspiration that is medically caused.
Effexor
withdrawal
Cardiovascular (Involving the heart and the blood
vessels)
Effexor
withdrawal
Palpitation
- Unusual and not normal heartbeat,
that is sometimes irregular, but rapid and forceful thumping or fluttering. It
can be brought on by shock, excitement, exertion, or medical stimulants. A
person is normally unaware of his/her heartbeat.
Effexor withdrawal
Hypertension
- is high blood pressure, which is a
symptom of disease in the blood vessels leading away from the heart.
Hypertension is known as the “silent killer”. The symptoms are usually not
obvious, however it can lead to damage to the heart, brain, kidneys and eye, and
even to stroke and kidney failure. Treatment includes dietary and lifestyle
changes.
Effexor withdrawal
Bradycardia
-
The heart rate is slowed from 72 beats per minute,
which is normal, to below 60 beats per minute in an adult.
Effexor
withdrawal
Tachycardia
- The heart rate is speeded up to
above 100 beats per minute in an adult. Normal adult heart rate is 72 beats per
minute.
Effexor
withdrawal
ECG Abnormal
-
A test
called an electrocardiogram (ECG) that records the activity of the heart. It
measures heartbeats as will as the position and size of the heart’s four
chambers. It also measures if there is damage to the heart and the effects of
drugs or mechanical devices like a pacemaker on the heart. When the test is
abnormal this means that one or more of the following are present: heart
disease, defects, beating too fast or too slow, disease of the blood vessels
leading from the heart or of the heart valves, and/or a past or about to occur
heart attack.
Effexor
withdrawal
Flushing
- The skin all over the body turns red.
Effexor withdrawal
Varicose Vein - Unusually swollen veins
near the surface of the skin that sometimes appear twisted and knotted, but
always enlarged. They are called hemorrhoids when they appear around the
rectum. The cause is attributed to hereditary weakness in the veins aggravated
by obesity, pregnancy, pressure from standing, aging, etc. Severe cases may
develop swelling in the legs, ankles and feet, eczema and/or ulcers in the
affected areas.
Effexor
withdrawal
Gastrointestinal
(Involving
the stomach and the intestines)
Effexor withdrawal
Abdominal Cramp/Pain
-
Sudden, severe, uncontrollable and painful shortening and
thickening of the muscles in the belly. The belly includes the stomach as well
as the intestines, liver, kidneys, pancreas, spleen, gall bladder, and urinary
bladder.
Effexor withdrawal
Belching
- Noisy release of gas from the stomach through the mouth; a burp.
Effexor
withdrawal
Bloating
- Swelling of the belly caused by excessive intestinal gas.
Effexor withdrawal
Constipation -
Difficulty in having a bowel movement where the material in the bowels is
hard due to a lack of exercise, fluid intake, and roughage in the diet, or due
to certain drugs.
Effexor withdrawal
Diarrhea - Unusually frequent and excessive, runny bowel movements that may
result in severe dehydration and shock.
Effexor
withdrawal
Dyspepsia - Indigestion. This is the discomfort you experience after eating. It
can be heartburn, gas, nausea, a bellyache or bloating.
Effexor withdrawal
Flatulence
- More gas than normal in the digestive organs.
Effexor withdrawal
Gagging
- Involuntary choking and/or involuntary throwing up.
Effexor withdrawal
Gastritis
- A severe irritation of the mucus lining of the stomach either short in
duration or lasting for a long period of time.
Effexor withdrawal
Gastroenteritis
-
A condition where the membranes
of the stomach and intestines are irritated.
Effexor
withdrawal
Gastroesophageal
Reflux - A
continuous state where stomach juices flow back into the throat causing acid
indigestion and heartburn and possibly injury to the throat.
Effexor
withdrawal
Heartburn
- A burning pain in the area of the breastbone caused by stomach juices flowing
back up into the throat.
Effexor withdrawal
Hemorrhoids - Small rounded
purplish swollen veins that either bleed, itch or are painful and appear around
the anus.
Effexor withdrawal
Increased Stool frequency
-
Diarrhea.
Effexor
withdrawal
Indigestion
- Unable to properly consume and absorb food in the digestive tract causing
constipation, nausea, stomach ache, gas, swollen belly, pain and general
discomfort or sickness.
Effexor withdrawal
Nausea - Stomach irritation with a queasy sensation similar to
motion sickness and a feeling that one is going to vomit.
Effexor
withdrawal
Polyposis Gastric
- Tumors that grow on stems in the lining of the stomach, which usually become
cancerous.
Effexor withdrawal
Swallowing Difficulty
- A feeling that food is stuck in the throat or upper chest area and won’t go
down, making it difficult to swallow.
Effexor withdrawal
Toothache
- Pain in a tooth above and below the gum line.
Effexor withdrawal
Vomiting
- Involuntarily throwing up the contents of the stomach and usually getting a
nauseated, sick feeling just prior to doing so.
Effexor
withdrawal
General
Effexor withdrawal
Allergy -
The extreme
sensitivity of body tissues triggered by substances in the air, drugs, or foods
causing a reaction like sneezing, itching, asthma, hay fever, skin rashes,
nausea and/or vomiting.
Effexor withdrawal
Anaphylaxis
- A violent, sudden, and severe drop
in blood pressure caused by a re-exposure to a foreign protein or a second
dosage of a drug that may be fatal unless emergency treatment is given right
away.
Effexor withdrawal
Asthenia
-
A physically
weak condition.
Effexor
withdrawal
Chest Pains
-
Severe discomfort in the chest caused by not enough oxygen going to the heart
because of narrowing of the blood vessels or spasms.
Effexor
withdrawal
Chills
-
Appearing
pale while cold and shivering; sometimes with a fever.
Effexor withdrawal
Edema of
Extremities
-
Abnormal
swelling of the body’s tissue caused by the collection of fluid.
Effexor withdrawal
Fall
- To suddenly lose your normal
standing upright position as if you were shot.
Effexor
withdrawal
Fatigue
- Loss of normal strength so as to
not be able to do the usual physical and mental activities.
Effexor
withdrawal
Fever
- Abnormally high body temperature,
the normal being 98 degrees Fahrenheit or 37 degrees Centigrade in humans, which
is a symptom of disease or disorder in the body. The body is affected by
feeling hot, chilled, sweaty, weak and exhausted. If the fever goes too high,
death can result.
Effexor
withdrawal
Hot Flashes
-
Brief,
abnormal enlargement of the blood vessels that causes a sudden heat sensation
over the entire body. Women in menopause will sometimes experience this.
Effexor
withdrawal
Influenza-like
Symptoms -
Demonstrating irritation of the respiratory tract (organs of breathing) such as
a cold, sudden fever, aches and pains, as well as feeling weak and seeking bed
rest, which is similar to having the flu.
Effexor
withdrawal
Leg Pain
- A
hurtful sensation in the legs that is caused by excessive stimulation of the
nerve endings in the legs and results in extreme discomfort.
Effexor withdrawal
Malaise -
The somewhat
unclear feeling of discomfort you get when you start to feel sick.
Effexor
withdrawal
Pain in Limb
-
Sudden, sharp and uncontrolled leg discomfort.
Effexor
withdrawal
Syncope
-
A short
period of light headedness or unconsciousness (black-out) also know as fainting
caused by lack of oxygen to the brain because of an interruption in blood
flowing to the brain.
Effexor withdrawal
Tightness of
Chest -
Mild or sharp discomfort, tightness
or pressure in the chest area (anywhere between the throat and belly). The
causes can be mild or seriously life-threatening because they include the heart,
lungs and surrounding muscles.
Effexor
withdrawal
Hemic and Lymphatic Disorders
(Involving
the blood and the clear fluids in the tissues that contain white blood cells)
Effexor withdrawal
Bruise
- Damage to the skin resulting in a
purple-green-yellow skin coloration that’s caused by breaking the blood vessels
in the area without breaking the surface of the skin.
Effexor
withdrawal
Anemia
-
A condition
where the blood is no longer carrying enough oxygen, so the person looks pale
and easily gets dizzy, weak and tired. More severely, a person can end up with
an abnormal heart, as well as breathing and digestive difficulties. The causes
of anemia are not enough protein in the red blood cells, or missing and
chemically destroyed red blood cells, as well as diseased or destroyed bone
marrow.
Effexor withdrawal
Nosebleed
- Blood lost from the part of the
face that has the organs of smell and is where the body takes in oxygen.
Effexor
withdrawal
Hematoma
- Broken blood vessels that cause a
swelling in an area on the body.
Effexor
withdrawal
Lymphadenopathy
Cervical
-
The lymph
nodes in the neck, which are part of the body’s immune system get swollen and
enlarge by reacting to the presence of a drug. The swelling is the result of
the white blood cells multiplying in order to fight the invasion of the drug.
Effexor
withdrawal
Metabolic and Nutritional Disorders
(Energy
and health)
Effexor
withdrawal
Arthralgia
-
Sudden sharp
nerve pain in one or more joints.
Effexor
withdrawal
Arthropathy
- Having joint disease or abnormal
joints.
Effexor
withdrawal
Arthritis
-
Painfully inflamed and swollen joints. The reddened
and swollen condition is brought on by a serious injury or shock to the body
either from physical or emotional causes.
Effexor
withdrawal
Back Discomfort
- Severe physical distress in the area from the neck to the pelvis along the
backbone.
Effexor withdrawal
Bilirubin Increased
- Bilirubin is a waste product of the breakdown
of old blood cells. Bilirubin is sent to the liver to be made water-soluble so
it can be eliminated from the body through emptying the bladder. A drug can
interfere with or damage this normal liver function creating liver disease.
Effexor withdrawal
Decreased Weight
- Uncontrolled and measured loss of heaviness or weight.
Effexor
withdrawal
Gout
- A severe arthritis condition that is caused by the dumping of a waste product
called uric acid in the tissues and joints. It can become worse and cause the
body to develop a deformity after going through stages of pain, inflammation,
severe tenderness, and stiffness.
Effexor withdrawal
Hepatic Enzymes Increased - An increase in the amount of paired liver proteins that
regulate liver processes causing a condition where the liver functions
abnormally.
Effexor withdrawal
Hypercholesterolemia
- Too much cholesterol in the blood cells.
Effexor
withdrawal
Hyperglycemia
- An unhealthy amount of sugar in the blood.
Effexor withdrawal
Increased Weight - A concentration and storage of fat in the body
accumulating over a period of time caused by unhealthy eating patterns, that can
predispose the body to many disorders and diseases.
Effexor
withdrawal
Jaw Pain - The pain due to irritation and swelling of the nerves associated with
the mouth area where it opens and closes just in front of the ear. Some of the
symptoms are pain when chewing, head aches, losing your balance, stuffy ears or
ringing in the ears, and teeth grinding.
Effexor withdrawal
Jaw Stiffness
- The result of squeezing and grinding the teeth while asleep that can cause
your teeth to deteriorate as well as the muscles and joints of the jaw.
Effexor
withdrawal
Joint Stiffness
- A loss of free motion and easy flexibility where any
two bones come together.
Effexor withdrawal
Muscle Cramp - When muscles contract uncontrollably without warning and do not
relax. The muscles of any of the body’s organs can cramp.
Effexor
withdrawal
Muscle Stiffness
- Tightening of muscles making it difficult to bend.
Effexor
withdrawal
Muscle Weakness
- Loss of physical strength.
Effexor
withdrawal
Myalgia - A general widespread pain and tenderness of the muscles.
Effexor
withdrawal Thirst
- A strong,
unnatural craving for moisture/water in the mouth and throat.
Effexor
withdrawal
Nervous System (Sensory channels)
Effexor withdrawal
Carpal Tunnel
Syndrome - A pinched
nerve in the wrist that causes pain, tingling, and numbing.
Effexor withdrawal
Coordination Abnormal - A lack of normal, harmonious interaction of the parts of
the body when it is in motion.
Effexor withdrawal
Dizziness - Losing one’s balance while feeling unsteady and lightheaded which may
lead to fainting.
Effexor
withdrawal
Disequilibrium
- Lack of mental and emotional balance.
Effexor withdrawal
Faintness - A temporary condition where one is likely to go
unconscious and fall.
Effexor withdrawal
Headache - A sharp or dull persistent pain in the head
Effexor
withdrawal
Hyperreflexia - A not normal and involuntary increased response in the
tissues connecting the bones to the muscles.
Effexor
withdrawal
Light-headed
Feeling –
Uncontrolled and usually brief loss of consciousness caused by lack of oxygen to
the brain.
Effexor
withdrawal
Migraine
- Reoccurring severe head pain usually with nausea, vomiting, dizziness, flashes
or spots before the eyes, and ringing in the ears
Effexor withdrawal
Muscle Contractions Involuntary
- Spontaneous and uncontrollable tightening reaction of the muscles caused by
electrical impulses from the nervous system.
Effexor
withdrawal
Muscular Tone Increased - Uncontrolled and exaggeration muscle tension. Muscles are
normally partially tensed and this is what gives us muscle tone.
Effexor
withdrawal
Paresthesia - Burning, prickly, itchy, or tingling skin with no obvious or
understood physical cause.
Effexor withdrawal
Restless Legs
- A need to move the legs without any apparent reason. Sometimes there is pain,
twitching, jerking, cramping, burning, or a creepy-crawly sensation associated
with the movements. It worsens when a person is inactive and can interrupt
one’s sleep so one feels the need to move to gain some relief.
Effexor
withdrawal
Shaking
- Uncontrolled quivering and trembling as if one is cold and chilled.
Effexor
withdrawal
Sluggishness
- Lack of alertness and energy, as well as being slow to respond or perform in
life.
Effexor withdrawal
Tics - A contraction of a muscle causing a repeated movement not
under the control of the person usually on the face or limbs.
Effexor
withdrawal
Tremor
- A nervous and involuntary vibrating or quivering of the body.
Effexor withdrawal
Twitching - Sharp, jerky and spastic motion sometimes with a
sharp sudden pain.
Effexor
withdrawal
Vertigo
- A sensation of dizziness with disorientation and confusion.
Effexor
withdrawal Psychiatric Disorders (Mental and emotional)
Effexor withdrawal
Aggravated Nervousness
- A progressively worsening, irritated and troubled state of mind.
Effexor
withdrawal
Agitation
- Suddenly violent and forceful, emotionally disturbed state of mind.
Effexor withdrawal
Amnesia - Long term or short term, partial or full memory loss created by
emotional or physical shock, severe illness, or a blow to the head where the
person was caused pain and became unconsciousness.
Effexor
withdrawal
Anxiety Attack
- Sudden and intense feelings of fear, terror, and dread physically creating
shortness of breath, sweating, trembling and heart palpitations.
Effexor withdrawal
Apathy
- Complete lack of concern or interest for things that ordinarily would be
regarded as important or would normally cause concern.
Effexor
withdrawal
Appetite
Decreased - Having a
lack of appetite despite the ordinary caloric demands of living with a resulting
unintentional loss of weight.
Effexor
withdrawal
Appetite
Increased - An
unusual hunger causing one to overeat.
Effexor
withdrawal
Auditory
Hallucination -
Hearing things without the voices or noises being present.
Effexor
withdrawal
Bruxism -
Grinding and clenching of teeth while sleeping.
Effexor withdrawal
Carbohydrate
Craving - A drive
and craving to eat foods rich in sugar and starches (sweets, snacks and junk
foods) that intensifies as the diet becomes more and more unbalanced due to the
unbalancing of the proper nutritional requirements of the body.
Effexor withdrawal
Concentration Impaired
- Unable to easily focus your attention for long periods of time.
Effexor
withdrawal
Confusion
- Not able to think clearly and understand in order to make a logical decision.
Effexor
withdrawal
Crying Abnormal
- Unusual and not normal fits of weeping for short or long periods of time for
no apparent reason.
Effexor withdrawal
Depersonalization
- A condition where one has lost a normal sense of personal identity.
Effexor
withdrawal
Depression
- A hopeless feeling of failure, loss and sadness that can deteriorate into
thoughts of death.
Effexor
withdrawal
Disorientation
- A loss of sense of direction, place, time or surroundings as well as mental
confusion on personal identity.
Effexor
withdrawal
Dreaming Abnormal
- Dreaming that leaves a very clear, detailed picture and impression when awake
that can last for a long period of time and sometimes be unpleasant.
Effexor
withdrawal
Emotional
Lability
- Suddenly breaking out
in laughter or crying or doing both without being able to control the outburst
of emotion. These episodes are unstable as they are caused by things that
normally would not have this effect on an individual.
Effexor withdrawal
Excitability - Uncontrollably responding to stimuli.
Effexor withdrawal
Feeling Unreal - The awareness that one has an undesirable emotion like
fear but can’t seem to shake off the irrational feeling. For example, feeling
like one is going crazy but rationally knowing that it is not true. The quality
of this side effect resembles being in a bad dream and not being able to wake
up.
Effexor
withdrawal
Forgetfulness
- Unable to remember what one ordinarily would remember.
Effexor
withdrawal
Insomnia
- Sleeplessness caused by physical stress, mental stress or stimulants such as
coffee or medications; it is a condition of being abnormally awake when one
would ordinarily be able to fall and remain asleep.
Effexor
withdrawal
Irritability
- Abnormally annoyed in response to a stimulus.
Effexor withdrawal
Jitteriness - Nervous fidgeting without an apparent cause.
Effexor
withdrawal
Lethargy
- Mental and physical sluggishness and apathy that can deteriorate into an
unconscious state resembling deep sleep. A numbed state of mind.
Effexor
withdrawal
Libido Decreased
- An abnormal loss of sexual energy or desire.
Effexor withdrawal
Panic Reaction
- A sudden, overpowering, chaotic and confused mental state of terror resulting
in being doubt ridden often accompanied with hyperventilation, and extreme
anxiety.
Effexor
withdrawal
Restlessness
Aggravated - A
constantly worsening troubled state of mind characterized by the person being
increasingly nervous, unable to relax, and easily angered.
Effexor
withdrawal
Somnolence - Feeling sleepy all the time or having a condition of
semi-consciousness.
Effexor
withdrawal
Suicide Attempt
- An unsuccessful deliberate attack on one’s own life with the intention of
ending it.
Effexor
withdrawal
Suicidal Tendency
- Most likely will attempt to kill oneself.
Effexor withdrawal
Tremulousness
Nervous - Very
jumpy, shaky, and uneasy while feeling fearful and timid. The condition is
characterized by thoughts of dreading the future, involuntary quivering,
trembling, and feeling distressed and suddenly upset.
Effexor withdrawal
Yawning - involuntary opening of the mouth with deep inhalation of
air.
Effexor
withdrawal
Reproductive Disorder Female
Effexor
withdrawal
Breast Neoplasm
-
A tumor or cancer, of either of the two milk-secreting
organs on the chest of a woman.
Effexor
withdrawal
Menorrhagia
- Abnormally heavy menstrual period or a
menstrual flow that has continued for an unusually long period of time.
Effexor
withdrawal
Menstrual Cramps
- Painful, involuntary uterus contractions that women experience around the time
of their menstrual period, sometimes causing pain in the lower back and thighs.
Effexor
withdrawal
Menstrual
Disorder - A disturbance or derangement in the normal function of a woman’s
menstrual period.
Effexor
withdrawal
Pelvic
Inflammation - The reaction of the body to infectious, allergic, or chemical
irritation, which in turn causes tissue irritation, injury, or bacterial
infection characterized by pain, redness, swelling, and sometimes loss of
function. The reaction usually begins in the uterus and spreads to the
fallopian tubes, ovaries, and other areas
in the hipbone region of the body.
Effexor
withdrawal
Premenstrual
Syndrome - Various physical and mental symptoms commonly experienced by women of
childbearing age usually 2 to 7 days before the start of their monthly period.
There are over 150 symptoms including eating binges, behavioral changes,
moodiness, irritability, fatigue, fluid retention, breast tenderness, headaches,
bloating, anxiety, and depression. The symptoms cease shortly after the period
begins, and disappear with menopause.
Effexor
withdrawal
Spotting Between
Menses - Abnormal bleeding between periods. Unusual spotting
between menstrual cycles.
Effexor
withdrawal
RESPIRATORY SYSTEM
(Organs involved in breathing)
Effexor
withdrawal
Asthma
- A disease of the breathing system initiated by and allergic reaction
or a chemical with repeated attacks of coughing, sticky mucus, wheezing,
shortness of breath, and a tight feeling in the chest. The disease can reach a
state where it stops a person from exhaling, leading to unconsciousness and
death.
Effexor
withdrawal
Breath Shortness
-
Unnatural breathing using a lot off effort resulting in not enough air taken in
by the body.
Effexor
withdrawal
Bronchitis
- Inflammation of the two main
breathing tubes leading from the windpipe to the lungs. The disease is marked
with coughing, a low-grade fever, chest pains, and hoarseness, caused by an
allergic reaction.
Effexor
withdrawal
Coughing
- A cough is the response to an
irritation, such as mucus, that causes the muscles controlling the breathing
process to expel air from the lungs suddenly and noisily to keep the air
passages free from the irritating material.
Effexor
withdrawal
Laryngitis
- Inflammation of the voice box
characterized by hoarseness, sore throat, and coughing. It can be cause by
straining the voice or exposure to infectious, allergic or chemical irritation.
Effexor
withdrawal
Nasal Congestion
- The
presence of an abnormal amount of fluid in the nose.
Effexor
withdrawal
Pneumonia
Tracheitis - Bacterial infection of the air passageways and lungs that causes
redness, swelling and pain in the windpipe. Other symptoms are high fever,
chills, pain in the chest, difficulty in breathing, and coughing with mucus
discharge.
Effexor
withdrawal
Rhinitis
- Chemical irritation causing pain,
redness and swelling in the mucus membranes of the nose.
Effexor
withdrawal
Sinus Congestion
- The
mucus-lined areas of the bones in the face that are thought to help warm and
moisten air to the nose. These areas become clogged with excess fluid or
infected.
Effexor
withdrawal
Sinus Headache
- The
abnormal amount of fluid in the hollows of the face bone area especially around
the nose. This excess fluid creates pressure, causing pain in the head.
Effexor
withdrawal
Sinusitis
- The body reacting to chemical
irritation causing redness, swelling and pain in the area of the hollows in the
facial bones especially around the nose.
Effexor
withdrawal SKELETAL
Effexor withdrawal
Neck/Shoulder Pain
- Hurtful sensations
of the nerve endings caused by damage to the tissues in the neck and shoulder
signaling danger of disease.
Effexor
withdrawal
SKIN and APPENDAGES DISORDERS (Skin, legs and arms)
Effexor
withdrawal
Acne
- Eruptions of the oils glands of the
skin, especially on the face, marked by pimples, blackheads, whiteheads, bumps,
and more severely, by cysts and scarring.
Effexor withdrawal
Alopecia -
The loss of hair or baldness.
Effexor
withdrawal
Eczema
- A severe or continuing skin disease
marked by redness, crusting and scaling with watery blisters and itching. It is
often difficult to treat and will sometimes go away only to reappear again.
Effexor
withdrawal
Dermatitis
- Generally irritated skin that can
be caused by any of a number of irritating things such as parasites, fungus,
bacteria, or foreign substances
causing an allergic reaction. It is a general inflammation of the skin.
Effexor
withdrawal
Dry Lips
- The
lack of normal moisture in the fleshy folds that surround the mouth.
Effexor withdrawal
Dry Skin - The lack of normal moisture/oils in the
surface layer of the body. The skin is the body’s largest organ.
Effexor withdrawal
Folliculitis
-
Inflammation of a follicle (small body sac) especially a hair follicle. A hair
follicle contains the root of a hair.
Effexor withdrawal
Furunculosis - Skin boils that show up repeatedly.
Effexor withdrawal
Lipoma - A tumor of mostly fat cells that is not health
endangering.
Effexor withdrawal
Pruritus
- Extreme itching of often-undamaged skin.
Effexor withdrawal
Rash - A skin eruption or discoloration that may or may not be
itching, tingling, burning, or painful. It may be caused by an allergy, an skin
irritation, a skin disease.
Effexor withdrawal
Skin Nodule - A bulge, knob, swelling or outgrowth in the skin
that is a mass of tissue or cells.
Effexor withdrawal
SPECIAL SENSES
Effexor withdrawal
Conjunctivitis
- Infection of the membrane that covers the eyeball and lines the eyelid, caused
by a virus, allergic reaction, or an irritating chemical. It is characterized
by redness, a discharge of fluid and itching.
Effexor withdrawal
Dry Eyes - Not enough moisture in the eyes.
Effexor withdrawal
Earache - Pain in the ear.
Effexor withdrawal
Eye Infection
- The invasion of the eye tissue by a bacteria, virus, fungus, etc, causing
damage to the tissue, with toxicity. Infection spreading in the body progresses
into disease.
Effexor withdrawal
Eye Irritation
- An inflammation of the eye.
Effexor withdrawal
Metallic Taste
- A range of taste impairment from distorted taste to a complete loss of taste.
Effexor withdrawal
Pupils Dilated
- Abnormal expansion of the blace circular opening in the center of the eye.
Effexor withdrawal
Taste alteration
- Abnormal flavor detection in food.
Effexor withdrawal
Tinnitus - A buzzing, ringing, or whistling sound in one or
both ears occurring from the internal use of certain drugs.
Effexor withdrawal
Vision Abnormal
- Normal images are seen differently by the viewer.
Effexor withdrawal
Vision Blurred
- Eyesight is dim or indistinct and hazy in outline or appearance.
Effexor withdrawal
Visual Disturbance
- Eyesight is interfered with or interrupted. Some disturbances are light
sensitivity and the inability to easily distinguish colors.
Effexor
withdrawal URINARY SYSTEM
DISORDER
Effexor
withdrawal
Blood in Urine
-
Blood is present when one empties liquid waste product of the kidneys through
the bladder by urinating in the toilet turning the water pink to bright red. Or
you could see pots of blood in the water after urinating.
Effexor
withdrawal
Dysuria
- Difficult or painful urination.
Effexor
withdrawal
Kidney Stone
- Small hard masses of salt deposits that the kidney forms.
Effexor
withdrawal
Urinary Frequency - Having to urinate more often than usual or between unusually short
time periods.
Effexor
withdrawal
Urinary Tract
Infection - An invasion of bacteria, viruses, fungi, etc., of the
system in the body that starts with the kidneys and eliminates urine from the
body. If the invasion goes unchecked it can injure tissue and progress into
disease.
Effexor
withdrawal
Urinary Urgency
- A sudden compelling urge to urinate, accompanied by discomfort in the bladder.
Effexor
withdrawal
UROGENITAL (Urinary tract and genital structures or functions)
Effexor
withdrawal
Anorgasmia
- Failure to experience an orgasm.
Effexor
withdrawal
Ejaculation
Disorder - Dysfunction of the discharge of semen during orgasm.
Effexor
withdrawal
Menstrual
Disorder - Dysfunction of the discharge during the monthly menstrual cycle.
Effexor withdrawal
Acute Renal
Failure - The kidneys
stop functioning properly to excrete wastes.
Effexor withdrawal
Angioedema
- Intensely itching and swelling welts on the skin called hives caused by an
allergic reaction to internal or external agents. The reaction is common to a
food or a drug. Chronic cases can last for a long period of time.
Effexor
withdrawal
Toxic Epidermal
Necrolysis - An abnormal condition where a large portion of skin
becomes intensely red and peels off like a second-degree burn. Often the
symptoms include blistering.
Effexor
withdrawal
Gastrointestinal
Hemorrhage - Stomach and intestinal excessive internal bleeding.
Effexor withdrawal
Grand Mal
Seizures (or Convulsions)
- A recurring sudden violent and involuntary attack of muscle spasms with a loss
of consciousness.
Effexor withdrawal
Neuroleptic Malignant Syndrome
- A life threatening, rare reaction to an anti-psychotic drug marked by fever,
muscular rigidity, changed mental status, and dysfunction of the autonomic
nervous system.
Effexor withdrawal
Pancreatitis - Chemical irritation with redness, swelling, and
pain in the pancreas where digestive enzymes and hormones are secreted.
Effexor withdrawal
QT Prolongation
- A very fast heart rhythm disturbance that is too fast for the heart to beat
effectively so the blood to the brain falls causing a sudden loss of
consciousness and may cause sudden cardiac death.
Effexor withdrawal
Rhabdomyolysis
- The breakdown of muscle fibers that releases the fibers into the circulatory
system. Some of the fibers are poisonous to the kidney and frequently result in
kidney damage.
Effexor withdrawal
Serotonin Syndrome
- A disorder brought on by excessive levels of serotonin caused by drugs and can
be fatal as death from this side effect can come very rapidly.
Effexor withdrawal
Thrombocytopenia
- An abnormal decrease in the number of blood platelets in the circulatory
system. A decrease in platelets would cause a decrease in the ability of the
blood to clot when necessary.
Effexor withdrawal
Torsades de Pointes
- Unusual rapid heart rhythm starting in the lower heart chambers. If the short
bursts of rapid heart rhythm continue for a prolonged period it can degenerate
into a more rapid rhythm and can be fatal.
Effexor
withdrawal. How to avoid
Effexor withdrawal side
effects
click here
Example of how an Effexor taper
can go:
Question:
I had been taking Effexor XR for close to 9 years
before tapering off. I used the plan from The Road to Recovery to
withdraw from 225 mg per day over a 10 week period. The withdrawal went quite
well with few side effects. I have been off Effexor completely for 3 weeks now
and the withdrawal symptoms are awful: brain zaps, irritability, headaches, body
aches, and I am so emotional I begin to weep at the drop of a hat. I am
continuing to take the supplements as directed in the plan, but things seem to
be getting worse instead of better. Suggestions? I need help.
Answer:
How much Omega 3 are you taking each day?
Give me a breakdown of what you are doing.
Somewhere at the time you were doing good and you
began to not feel well we will find the item to address.
Response:
Thank you for your prompt reply. I have been
taking 6 omega 3 caps/day; two in the morning, two around 11:00 am, and two
around 4:00 pm. I am also taking the barley grass powder-1tbs- at the same
times.
I am taking 4 tsp of cherry extract around
8:00 pm. I am sleeping quite well. In fact since I have been off Effexor
and taking the cherry extract I have stopped having the bizarre dreams that
have been a part of my life for so long.
I usually feel best early in the day. Depending
on my activity, level the side effects tend to get worse as the day goes
on. The more active I am, the more intense the brain zaps. I usually have
a headache by late afternoon-early evening. Once I take the cherry extract
and go to bed, the headache is gone.
I certainly will appreciate any feedback you can
give me.
Answer:
You might try taking 1 teaspoon of cherry
starting around noon, 4 pm, 8 pm and at bedtime as normal.
If the cherry at night gets rid of the headache,
odds are it will during the day as well.
Cherry should not make you tired during the day.
If it does, cut the amount back a little.
Response:
I have been taking the cherry concentrate 3x /
day as you suggested for five days now. I have definitely seen a reduction in
side effects. I am feeling much better, thank you!
I have been completely off Effexor for four
weeks. I would like you to know how much I appreciate your book and the help you
have given me. It is so wonderful to feel alive again. I have so much more
energy and interest in the activities going on around me. I have accomplished
more in the past few months than I have in the past few years.
Thanks again for the work you are doing. You
are truly making a difference in people's lives.
Venlafaxine
Brand name (Effexor)
Pharmacology
Antidepressant
Venlafaxine is a phenethylamine bicyclic derivative, chemically unrelated to tricyclic, tetracyclic or other available antidepressant agents.
The mechanism of venlafaxine's antidepressant action in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. Preclinical studies have shown that venlafaxine and its major metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and
weak inhibitors of dopamine reuptake.
Venlafaxine and ODV have no significant affinity for muscarinic, histaminergic, or alpha1-adrenergic receptors in vitro. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Venlafaxine and ODV do not possess
monoamine oxidase (MAO) inhibitory activity.
Pharmacokinetics:
Venlafaxine is well absorbed, with peak plasma concentrations occurring approximately 2 hours after dosing. Venlafaxine is extensively metabolized, with O-desmethylvenlafaxine, (ODV, the only major active metabolite) peak plasma levels occurring approximately 4 hours after dosing. Following single doses of 25 to 75 mg, mean (+/- SD) peak
plasma concentrations of venlafaxine range from 34+/-14 to 96+/-43 ng/mL, respectively, and are reached in 2+/-1 hours, and mean peak ODV plasma concentrations range from 58+/-18 to 178+/-40 ng/mL and are reached in 4+/-2 hours. Approximately 87% of a single dose of venlafaxine is recovered in the urine within 48 hours as either unchanged
venlafaxine (5%), unconjugated ODV (30%), conjugated ODV (26%), or other minor metabolites (27%).
Multiple-Dose Pharmacokinetic Profile:
Steady-state concentrations of both venlafaxine and ODV in plasma were attained after approximately 3 days of multiple dose therapy. The clearance of venlafaxine is slightly (15%) lower following multiple doses than following a single dose.
Venlafaxine and ODV exhibited linear kinetics over the dose range of 75 to 450 mg total daily dose administered t.i.d.
The mean +/- SD steady-state plasma clearances of venlafaxine and ODV are 1.3+/-0.6 and 0.4+/-0.2 L/h/kg, respectively; elimination half-life is 5+/-2 and 11+/-2 hours, respectively.
Venlafaxine and ODV renal clearances are 49+/-27 and 94+/-56 mL/h/kg, respectively, which correspond to 5+/-3.0% and 25+/-13% of an administered venlafaxine dose recovered in urine as venlafaxine and ODV, respectively. Similar steady-state volumes of distribution are exhibited for venlafaxine (7+/-4 L/kg) and ODV (6+/-2 L/kg).
Venlafaxine and ODV are less than 35% bound to plasma proteins. Therefore, protein-binding-induced drug interactions with venlafaxine are not expected.
Food has no significant effect on the absorption of venlafaxine.
When equal daily doses of venlafaxine were administered either b.i.d. or t.i.d., drug exposure (AUC) and fluctuation in plasma levels were comparable.
Age and Gender:
Age and sex do not significantly affect the pharmacokinetics of venlafaxine. A 20% reduction in clearance was noted for ODV in subjects over 60 years old; this was possibly caused by the decrease in renal function that typically occurs with aging. Dosage adjustment based upon age or gender is generally not necessary (See Dosage).
Hepatic Disease:
In 9 patients with hepatic cirrhosis, the |