Do you have a patient suffering from medication side effects? Do you have patients that are ready to get off their medications? A step-by-step method is now available. Insomnia, anxiety, head symptoms are the common withdrawal side effects from psychoactive drugs which stops most people from being able to completely get off their medication. Those symptoms no longer need to get in the way of a successful taper.

Deciding how fast to titrate off a medication can be a confusing decision. Which medication to taper first needs to based on drug/drug interactions associated with the CYP enzymes. Did you know, if you taper a patient off the antidepressant first, while they concurrently take a benzodiazepine, the patient will go into withdrawal on the benzodiazepine as well? Click here for the method used by physicians worldwide to taper patients off psychoactive medications.

Review by Dr. Hyla Cass M.D. Psychiatrist "Here is an essential handbook on how to safely and more easily wean yourself (under medical supervision) off the heavily over-prescribed psychotropic medications. I have used the program with my patients and it works!” Hyla Cass M.D. Author of Supplement Your Prescription

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Depakote Clinical Trials

Valproate-Associated Coagulopathies in Children During Short-Term Treatment.

Köse G, Arhan E, Unal B, Ozaydin E, Guven A, Sayli TR.

J Child Neurol. 2009 May 28. [Epub ahead of print]

PMID: 19482838 [PubMed - as supplied by publisher]

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[Hyperammonaemic encephalopathy due to valproic acid in the neonatal period]

Jiménez-Parrilla F, Pérez-Sánchez A, Núñez-Solís JM, Madruga-Garrido M, Losada-Martínez A.

Rev Neurol. 2009 Jun 1-15;48(11):613-4. Spanish. No abstract available.

PMID: 19472163 [PubMed - in process]

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Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatment.

Luef G, Rauchenzauner M, Waldmann M, Sturm W, Sandhofer A, Seppi K, Trinka E, Unterberger I, Ebenbichler CF, Joannidis M, Walser G, Bauer G, Hoppichler F, Lechleitner M.

Epilepsy Res. 2009 May 21. [Epub ahead of print]

PMID: 19464851 [PubMed - as supplied by publisher]

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Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions.

Fukuchi M, Nii T, Ishimaru N, Minamino A, Hara D, Takasaki I, Tabuchi A, Tsuda M.

Neurosci Res. 2009 May 20. [Epub ahead of print]

PMID: 19463867 [PubMed - as supplied by publisher]

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Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine.

Castro-Gago M, Gómez-Lado C, Eirís-Puñal J, Díaz-Mayo I, Castiñeiras-Ramos DE.

J Child Neurol. 2009 May 20. [Epub ahead of print]

PMID: 19458381 [PubMed - as supplied by publisher]

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Effects of valproic acid on sleep in children with epilepsy.

Schmitt B, Martin F, Critelli H, Molinari L, Jenni OG.

Epilepsia. 2009 May 12. [Epub ahead of print]

PMID: 19453719 [PubMed - as supplied by publisher]

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Epilepsy in Angelman syndrome: A questionnaire-based assessment of the natural history and current treatment options.

Thibert RL, Conant KD, Braun EK, Bruno P, Said RR, Nespeca MP, Thiele EA.

Epilepsia. 2009 May 12. [Epub ahead of print]

PMID: 19453717 [PubMed - as supplied by publisher]

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Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice.

Ghiglieri V, Picconi B, Sgobio C, Bagetta V, Barone I, Paillè V, Di Filippo M, Polli F, Gardoni F, Altrock W, Gundelfinger ED, De Sarro G, Bernardi G, Ammassari-Teule M, Di Luca M, Calabresi P.

Eur J Neurosci. 2009 May;29(10):1979-93. Epub 2009 May 9.

PMID: 19453636 [PubMed - in process]

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[Reversible dementia-like condition and parkinsonism in an elderly woman. Idiosyncratic adverse effects connected to 11 years of antiepileptic medication]

Lindbom U, Taubert B, Fahlqvist MS, Bergens A, Kimland E, Jonsson EW, Bergman U.

Lakartidningen. 2009 Mar 18-24;106(12):863-5. Swedish. No abstract available.

PMID: 19452788 [PubMed - indexed for MEDLINE]

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The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.

Samuni Y, Flores-Santana W, Krishna MC, Mitchell JB, Wink DA.

Free Radic Biol Med. 2009 May 14. [Epub ahead of print]

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Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo.

Selderslaghs IW, Van Rompay AR, De Coen W, Witters HE.

Reprod Toxicol. 2009 May 15. [Epub ahead of print]

PMID: 19447169 [PubMed - as supplied by publisher]

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Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.

Luszczki JJ.

Pharmacol Rep. 2009 Mar-Apr;61(2):197-216.

PMID: 19443931 [PubMed - in process]

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Phase II open label study of valproic acid in spinal muscular atrophy.

Swoboda KJ, Scott CB, Reyna SP, Prior TW, LaSalle B, Sorenson SL, Wood J, Acsadi G, Crawford TO, Kissel JT, Krosschell KJ, D'Anjou G, Bromberg MB, Schroth MK, Chan GM, Elsheikh B, Simard LR.

PLoS ONE. 2009;4(5):e5268. Epub 2009 May 14.

PMID: 19440247 [PubMed - in process]

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Efficacy of anti-epileptic drugs in patients with gliomas and seizures.

van Breemen MS, Rijsman RM, Taphoorn MJ, Walchenbach R, Zwinkels H, Vecht CJ.

J Neurol. 2009 May 12. [Epub ahead of print]

PMID: 19434440 [PubMed - as supplied by publisher]

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[Haematological adverse effects caused by psychiatric drugs]

Mazaira S.

Vertex. 2008 Nov-Dec;19(82):378-86. Spanish.

PMID: 19424521 [PubMed - in process]

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[Valproate-induced hyperammonemic encephalopathy. Cases review in the psychiatric setting]

Fassi G, Igoa A, Liste OA.

Vertex. 2008 Nov-Dec;19(82):371-7. Spanish.

PMID: 19424520 [PubMed - in process]

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Severe valproic acid intoxication: case study on the unbound fraction and the applicability of extracorporeal elimination.

van den Broek MP, Sikma MA, Ververs TF, Meulenbelt J.

Eur J Emerg Med. 2009 May 6. [Epub ahead of print]

PMID: 19424075 [PubMed - as supplied by publisher]

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Effects of a dopamine receptor agonist and atropine sulfate on absorption of valproic acid in rats.

Kameya H, Hokama N, Hobara N, Ohshiro S, Uno T.

Biomed Res. 2009 Apr;30(2):101-6.

PMID: 19420733 [PubMed - in process]

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[Iatrogenic demential and extrapyramidal syndrome: rare adverse effect of valproic acid-aspirin combination.]

Penot JP, Pradeau F.

Presse Med. 2009 May 4. [Epub ahead of print] French. No abstract available.

PMID: 19419832 [PubMed - as supplied by publisher]

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Skeletal sequelae of cancer and cancer treatment.

Stava CJ, Jimenez C, Hu MI, Vassilopoulou-Sellin R.

J Cancer Surviv. 2009 May 2. [Epub ahead of print]

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A review of valproate in psychiatric practice.

Haddad PM, Das A, Ashfaq M, Wieck A.

Expert Opin Drug Metab Toxicol. 2009 May;5(5):539-51.

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Mood stabilizers increase prepulse inhibition in DBA/2NCrl mice.

Flood DG, Choinski M, Marino MJ, Gasior M.

Psychopharmacology (Berl). 2009 Apr 29. [Epub ahead of print]

PMID: 19404613 [PubMed - as supplied by publisher]

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Acquired von Willebrand syndrome as side effect of valproic acid therapy in children is rare.

Eberl W, Budde U, Bentele K, Christen HJ, Knapp R, Mey A, Schneppenheim R.

Hamostaseologie. 2009 May;29(2):137-42.

PMID: 19404518 [PubMed - in process]

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Charles Bonnet syndrome disappearing with carbamazepine and valproic acid but not with levetiracetam.

Segers K.

Acta Neurol Belg. 2009 Mar;109(1):42-3.

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Molecular Pathology of Neuro-AIDS (CNS-HIV).

Crews L, Patrick C, Achim CL, Everall IP, Masliah E.

Int J Mol Sci. 2009 Mar;10(3):1045-63. Epub 2009 Mar 11.

PMID: 19399237 [PubMed - in process]

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Inhibition of Growth in Medullary Thyroid Cancer Cells with Histone Deacetylase Inhibitors and Lithium Chloride.

Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H.

J Surg Res. 2008 Sep 4. [Epub ahead of print]

PMID: 19394967 [PubMed - as supplied by publisher]

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Variation in glucuronidation of lamotrigine in human liver microsomes.

Argikar UA, Remmel RP.

Xenobiotica. 2009 May;39(5):355-63.

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Chronic dietary administration of valproic Acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic Acid neurotoxicity.

Eleuteri S, Monti B, Brignani S, Contestabile A.

Neurotox Res. 2009 Feb;15(2):127-32. Epub 2009 Mar 4.

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The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy.

Lunke S, El-Osta A.

J Neurochem. 2009 Apr 28. [Epub ahead of print]

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[Reversed Effect of Valproic Acid on Transcription Inhibition of AML1-ETO Fusion Protein of Kasumi-1 Leukemic Cell Line.]

Zhao L, Zhu CM, Zhang ZH, Tian WL, Hao CL.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):363-7. Chinese.

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Chemical synthesis of bile acid acyl-adenylates and formation by a rat liver microsomal fraction.

Ikegawa S, Ito H, Ohshima M, Maeda M, Hofmann AF, Mitamura K.

Steroids. 2009 Apr 17. [Epub ahead of print]

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Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivo.

Kortenhorst MS, Isharwal S, van Diest PJ, Chowdhury WH, Marlow C, Carducci MA, Rodriguez R, Veltri RW.

Mol Cancer Ther. 2009 Apr;8(4):802-8.

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Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway.

Cournoyer P, Desrosiers RR.

Neuropharmacology. 2009 Apr;56(5):839-48. Epub 2009 Jan 19.

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Evaluation of the effects of propylisopropylacetic acid (PIA) on neuronal growth cone morphology.

Shimshoni JA, Dalton EC, Watson P, Yagen B, Bialer M, Harwood AJ.

Neuropharmacology. 2009 Jan 20. [Epub ahead of print]

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Unrecognized valproic acid intoxication.

Hurdle AC, Moss RD.

Am J Emerg Med. 2009 Feb;27(2):250.e1-2.

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Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.

Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group.

N Engl J Med. 2009 Apr 16;360(16):1597-605.

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Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells.

Morita K, Gotohda T, Arimochi H, Lee MS, Her S.

J Neurosci Res. 2009 Apr 9. [Epub ahead of print]

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Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin.

Kim TH, Yoo YH, Kang DY, Suh H, Park MK, Park KJ, Kim SH.

Int J Oncol. 2009 May;34(5):1353-62.

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Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats.

Fatemi SH, Reutiman TJ, Folsom TD.

Schizophr Res. 2009 Jun;111(1-3):138-152. Epub 2009 Apr 9.

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Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibiotics.

Nakamura Y, Nakahira K, Mizutani T.

Drug Metab Lett. 2008 Dec;2(4):280-5.

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Inhibition of histone deacetylases: a pharmacological approach to the treatment of non-cancer disorders.

Wiech NL, Fisher JF, Helquist P, Wiest O.

Curr Top Med Chem. 2009;9(3):257-71.

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[Antiepileptic drugs for the prevention of pediatric migraine.]

Cuvellier JC.

Rev Neurol (Paris). 2009 Apr 3. [Epub ahead of print] French.

PMID: 19345966 [PubMed - as supplied by publisher]

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Valproic acid delayed release (Stavzor).

[No authors listed]

Med Lett Drugs Ther. 2009 Apr 6;51(1309):27-8. No abstract available.

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Epigenetic Influences on Sensory Regeneration: Histone Deacetylases Regulate Supporting Cell Proliferation in the Avian Utricle.

Slattery EL, Speck JD, Warchol ME.

J Assoc Res Otolaryngol. 2009 Apr 2. [Epub ahead of print]

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An experimental design for finding of minimum dosage of carbamazepine and valproate in preventing of seizure attacks.

Samaei A, Nobahar M, Vafaei AA.

Pak J Pharm Sci. 2009 Apr;22(2):180-3.

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Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.

Yusa K, Rad R, Takeda J, Bradley A.

Nat Methods. 2009 May;6(5):363-9. Epub 2009 Mar 31.

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Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model.

Barcia JA, Gallego JM.

Neurotherapeutics. 2009 Apr;6(2):337-43.

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Analysis of Neuroprotective Effects of Valproic Acid on Primary Motor Neurons in Monoculture or Co-cultures with Astrocytes or Schwann Cells.

Ragancokova D, Jahn K, Kotsiari A, Schlesinger F, Haastert K, Stangel M, Petri S, Krampfl K.

Cell Mol Neurobiol. 2009 Mar 28. [Epub ahead of print]

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Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat.

Aktaş Z, Cansu A, Erdoğan D, Take G, Goktas G, Ozdek S, Serdaroglu A.

Seizure. 2009 Mar 27. [Epub ahead of print]

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Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells.

Yamauchi J, Miyamoto Y, Torii T, Mizutani R, Nakamura K, Sanbe A, Koide H, Kusakawa S, Tanoue A.

Exp Cell Res. 2009 Mar 25. [Epub ahead of print]

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[Cognitive impairment and parkinsonism due to use of sodium valproate]

Schreur L, Middeljans-Tijssen CW, Hengstman GJ, Olde Rikkert MG.

Tijdschr Gerontol Geriatr. 2009 Feb;40(1):29-33. Dutch.

PMID: 19326700 [PubMed - indexed for MEDLINE]

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Adverse events with use of antiepileptic drugs: a prescription and event symmetry analysis.

Tsiropoulos I, Andersen M, Hallas J.

Pharmacoepidemiol Drug Saf. 2009 Mar 26. [Epub ahead of print]

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Differential effects of valproic acid on growth, proliferation and metastasis in HTB5 and HTB9 bladder cancer cell lines.

Byun SS, Kim FJ, Khandrika L, Kumar B, Koul S, Wilson S, Koul HK.

Cancer Lett. 2009 Mar 24. [Epub ahead of print]

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Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009.

Shorvon SD.

Epilepsia. 2009 Mar;50 Suppl 3:93-130.

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Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.

Dedes KJ, Dedes I, Imesch P, von Bueren AO, Fink D, Fedier A.

Anticancer Drugs. 2009 Jun;20(5):321-33.

PMID: 19322073 [PubMed - in process]

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Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC.

Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, Daud A, Neuger A, Minton S, Sullivan D.

Clin Cancer Res. 2009 Apr 1;15(7):2488-96. Epub 2009 Mar 24.

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Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial.

Daud AI, Dawson J, DeConti RC, Bicaku E, Marchion D, Bastien S, Hausheer FA 3rd, Lush R, Neuger A, Sullivan DM, Munster PN.

Clin Cancer Res. 2009 Apr 1;15(7):2479-87. Epub 2009 Mar 24.

PMID: 19318485 [PubMed - in process]

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Refractory restless legs syndrome likely caused by olanzapine.

Khalid I, Rana L, Khalid TJ, Roehrs T.

J Clin Sleep Med. 2009 Feb 15;5(1):68-9.

PMID: 19317385 [PubMed - indexed for MEDLINE]

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[When a seizure occurs...]

Sadzot B, Moonen G.

Rev Med Liege. 2009 Jan;64(1):58-62. French.

PMID: 19317105 [PubMed - indexed for MEDLINE]

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Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database.

Bondon-Guitton E, Sommet A, Montastruc JL; French Association of Regional Pharmacovigilance Centres.

Pharmacopsychiatry. 2009 Mar;42(2):61-5. Epub 2009 Mar 23.

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Clinical alertness to valproic acid-induced hyperammonemia--two case reports.

Shan J, Hsieh M, Liu C, Wen C, Liu C.

J Psychopharmacol. 2009 Mar 20. [Epub ahead of print] No abstract available.

PMID: 19304858 [PubMed - as supplied by publisher]

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[Effect of valproic acid on the expression of P27(Kip1) and P170 and drug resistance of HL-60/HT cells.]

Li YQ, Yin SM, Xie SF, Ma LP, Nie DN, Wang XJ, Wu YD.

Nan Fang Yi Ke Da Xue Xue Bao. 2009 Mar;29(3):423-7. Chinese.

PMID: 19304516 [PubMed - in process]

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The supra-additive hyperactivity caused by an amphetamine-chlordiazepoxide mixture exhibits an inverted-U dose response: negative implications for the use of a model in screening for mood stabilizers.

Kelly MP, Logue SF, Dwyer JM, Beyer CE, Majchrowski H, Cai Z, Liu Z, Adedoyin A, Rosenzweig-Lipson S, Comery TA.

Pharmacol Biochem Behav. 2009 Jun;92(4):649-54. Epub 2009 Mar 18.

PMID: 19303035 [PubMed - in process]

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Neuroleptic malignant syndrome secondary to quetiapine.

Gortney JS, Fagan A, Kissack JC.

Ann Pharmacother. 2009 Apr;43(4):785-91. Epub 2009 Mar 18.

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Hyperammonemia following intravenous valproate loading.

Dewolfe JL, Knowlton RC, Beasley MT, Cofield S, Faught E, Limdi NA.

Epilepsy Res. 2009 Mar 17. [Epub ahead of print]

PMID: 19299111 [PubMed - as supplied by publisher]

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Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.

Pessah N, Bialer M, Wlodarczyk B, Finnell RH, Yagen B.

J Med Chem. 2009 Apr 23;52(8):2233-42.

PMID: 19296679 [PubMed - indexed for MEDLINE]

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Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis.

Crochemore C, Virgili M, Bonamassa B, Canistro D, Pena-Altamira E, Paolini M, Contestabile A.

Muscle Nerve. 2009 Apr;39(4):548-52.

PMID: 19296491 [PubMed - indexed for MEDLINE]

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[Valproic acid induced intracellular GSH-redox imbalance and apoptosis of leukemic cells resistant to dexamethasone and doxorubicin]

Liu H, Fu RY, Liao QK, Li FY, Zhu YP, Gao J, Mao YQ.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jan;40(1):133-7. Chinese.

PMID: 19292063 [PubMed - in process]

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Maintenance treatment for patients with bipolar I disorder: results from a north american study of quetiapine in combination with lithium or divalproex (trial 127).

Suppes T, Vieta E, Liu S, Brecher M, Paulsson B; Trial 127 Investigators.

Am J Psychiatry. 2009 Apr;166(4):476-88. Epub 2009 Mar 16.

PMID: 19289454 [PubMed - indexed for MEDLINE]

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Antipsychotics affect multiple calcium calmodulin dependent proteins.

Rushlow WJ, Seah C, Sutton LP, Bjelica A, Rajakumar N.

Neuroscience. 2009 Jul 7;161(3):877-886. Epub 2009 Mar 13.

PMID: 19289156 [PubMed - as supplied by publisher]

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Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway.

Moon BS, Yoon JY, Kim MY, Lee SH, Choi T, Choi KY.

Exp Mol Med. 2009 Feb 28;41(2):116-25.

PMID: 19287192 [PubMed - indexed for MEDLINE]

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Effect of concomitant administration of meropenem and valproic acid in an elderly Chinese patient.

Gu J, Huang Y.

Am J Geriatr Pharmacother. 2009 Feb;7(1):26-33.

PMID: 19281938 [PubMed - indexed for MEDLINE]

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Antiepileptic drug interactions.

Díaz RA, Sancho J, Serratosa J.

Neurologist. 2008 Nov;14(6 Suppl 1):S55-65. Review.

PMID: 19225371 [PubMed - indexed for MEDLINE]

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Carnitine in the treatment of valproic acid-induced toxicity.

Lheureux PE, Hantson P.

Clin Toxicol (Phila). 2009 Feb;47(2):101-11. Review.

PMID: 19280426 [PubMed - indexed for MEDLINE]

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Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells.

Fuchs O, Provaznikova D, Marinov I, Kuzelova K, Spicka I.

Cardiovasc Hematol Disord Drug Targets. 2009 Mar;9(1):62-77. Review.

PMID: 19275578 [PubMed - indexed for MEDLINE]

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Microarray analysis of murine limb bud ectoderm and mesoderm after exposure to cadmium or acetazolamide.

Schreiner CM, Bell SM, Scott WJ Jr.

Birth Defects Res A Clin Mol Teratol. 2009 Mar 9. [Epub ahead of print]

PMID: 19274763 [PubMed - as supplied by publisher]

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Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use.

Herzog AG, Blum AS, Farina EL, Maestri XE, Newman J, Garcia E, Krishnamurthy KB, Hoch DB, Replansky S, Fowler KM, Smithson SD, Dworetzky BA, Bromfield EB.

Neurology. 2009 Mar 10;72(10):911-4.

PMID: 19273825 [PubMed - indexed for MEDLINE]

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Commentary to: "Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid".

Belcastro V, Striano P.

Brain Dev. 2009 Jun;31(6):474. Epub 2009 Mar 5. No abstract available.

PMID: 19268510 [PubMed - in process]

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Is survival enough for myelodysplastic syndromes?

Santini V.

Leuk Res. 2009 Aug;33(8):1017-8. Epub 2009 Mar 5. No abstract available.

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A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability.

Ten Cate B, Bremer E, de Bruyn M, Bijma T, Samplonius D, Schwemmlein M, Huls G, Fey G, Helfrich W.

Leukemia. 2009 Mar 5. [Epub ahead of print]

PMID: 19262596 [PubMed - as supplied by publisher]

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Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy.

Yiş U, Seçkin E, Kurul SH, Kuralay F, Dirik E.

Epilepsy Res. 2009 Apr;84(2-3):232-7. Epub 2009 Mar 3.

PMID: 19261443 [PubMed - in process]

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Glutaric aciduria type 1 presenting with epilepsy.

McClelland VM, Bakalinova DB, Hendriksz C, Singh RP.

Dev Med Child Neurol. 2009 Mar;51(3):235-9.

PMID: 19260933 [PubMed - indexed for MEDLINE]

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Weight gain in children treated with valproate.

Sharpe C, Wolfson T, Trauner DA.

J Child Neurol. 2009 Mar;24(3):338-41.

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Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy.

Gorkemli H, Genc BO, Dogan EA, Genc E, Ozdemir S.

Gynecol Obstet Invest. 2009;67(4):223-7. Epub 2009 Feb 24.

PMID: 19246930 [PubMed - in process]

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'Nother one for Narcan.

Tabano C.

JEMS. 2009 Jan;34(1):20. No abstract available.

PMID: 19245950 [PubMed - indexed for MEDLINE]

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Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus.

Chen L, Feng P, Wang J, Liu L, Zhou D.

J Clin Neurosci. 2009 Apr;16(4):524-6. Epub 2009 Feb 24.

PMID: 19243950 [PubMed - indexed for MEDLINE]

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Association between consistent purchase of anticonvulsants or lithium and suicide risk: A longitudinal cohort study from Denmark, 1995-2001.

Smith EG, Søndergård L, Lopez AG, Andersen PK, Kessing LV.

J Affect Disord. 2009 Feb 23. [Epub ahead of print]

PMID: 19243837 [PubMed - as supplied by publisher]

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Doripenem monohydrate, a broad-spectrum carbapenem antibiotic.

Matthews SJ, Lancaster JW.

Clin Ther. 2009 Jan;31(1):42-63. Review.

PMID: 19243706 [PubMed - indexed for MEDLINE]

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Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study.

Elger C, Halász P, Maia J, Almeida L, Soares-da-Silva P; BIA-2093-301 Investigators Study Group.

Epilepsia. 2009 Mar;50(3):454-63. Epub 2009 Feb 21.

PMID: 19243424 [PubMed - indexed for MEDLINE]

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Anticonvulsant medications in the pediatric emergency room and intensive care unit.

Abend NS, Huh JW, Helfaer MA, Dlugos DJ.

Pediatr Emerg Care. 2008 Oct;24(10):705-18; quiz 719-21. Review.

PMID: 19240677 [PubMed - indexed for MEDLINE]

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Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide.

Neyns B, Hoorens A, Stupp R.

Acta Neurol Belg. 2008 Dec;108(4):131-4.

PMID: 19239041 [PubMed - indexed for MEDLINE]

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Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability.

Li X, Ricci R, Large CH, Anderson B, Nahas Z, George MS.

J Neural Transm. 2009 Apr;116(4):423-9. Epub 2009 Feb 24.

PMID: 19238517 [PubMed - in process]

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Status epilepticus: a critical review.

Knake S, Hamer HM, Rosenow F.

Epilepsy Behav. 2009 May;15(1):10-4. Epub 2009 Feb 21.

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Long-term safety of divalproex sodium extended-release in children and adolescents with bipolar I disorder.

Redden L, DelBello M, Wagner KD, Wilens TE, Malhotra S, Wozniak P, Vigna NV, Greco N 4th, Kovacs X, Abi-Saab W, Saltarelli M; Depakote ER Pediatric Mania Group.

J Child Adolesc Psychopharmacol. 2009 Feb;19(1):83-9.

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Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study.

Chang K, Karchemskiy A, Kelley R, Howe M, Garrett A, Adleman N, Reiss A.

J Child Adolesc Psychopharmacol. 2009 Feb;19(1):51-9.

PMID: 19232023 [PubMed - indexed for MEDLINE]

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[Presurgical video EEG monitoring of lesional epilepsy patients]

Oehl B, Altenmüller DM, Schulze-Bonhage A.

Nervenarzt. 2009 Apr;80(4):464-7. German.

PMID: 19229508 [PubMed - in process]

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[Unverricht-Lundborg disease manifesting tremulous myoclonus with rare convulsive seizures: a case report]

Kondo T, Yamakado H, Kawamata J, Tomimoto H, Hitomi T, Takahashi R, Ikeda A.

Rinsho Shinkeigaku. 2009 Jan;49(1):43-7. Japanese.

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Anti-leukemic activity of valproic acid and imatinib mesylate on human Ph+ ALL and CML cells in vitro.

Kircher B, Schumacher P, Petzer A, Hoflehner E, Haun M, Nachbaur D, Gastl G.

Eur J Haematol. 2009 Feb 17. [Epub ahead of print]

PMID: 19226363 [PubMed - as supplied by publisher]

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In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis.

Fujimura H, Murakami N, Kurabe M, Toriumi W.

J Appl Toxicol. 2009 May;29(4):356-63.

PMID: 19224547 [PubMed - in process]

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Diagnosis and management of the primary headache disorders in the emergency department setting.

Friedman BW, Grosberg BM.

Emerg Med Clin North Am. 2009 Feb;27(1):71-87, viii. Review.

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[Meropenem and valproic acid. An interaction to remember]

San Antonio Arce V, Joyanes Abancens B.

An Pediatr (Barc). 2009 Feb;70(2):193-4. Epub 2008 Nov 17. Spanish. No abstract available.

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Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr(-/-) murine model of autoimmune lymphoproliferative syndrome (ALPS).

Dowdell KC, Pesnicak L, Hoffmann V, Steadman K, Remaley AT, Cohen JI, Straus SE, Rao VK.

Exp Hematol. 2009 Apr;37(4):487-94. Epub 2009 Feb 12.

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Valproic acid induces transcriptional activation of human GD3 synthase (hST8Sia I) in SK-N-BE(2)-C human neuroblastoma cells.

Kwon HY, Dae HM, Song NR, Kim KS, Kim CH, Lee YC.

Mol Cells. 2009 Jan;27(1):113-8. Epub 2008 Oct 13.

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Antiapoptotic action of lithium and valproate.

Bielecka AM, Obuchowicz E.

Pharmacol Rep. 2008 Nov-Dec;60(6):771-82. Review.

PMID: 19211968 [PubMed - indexed for MEDLINE]

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Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: a prospective double-blind randomized placebo-controlled study.

Agrawal RP, Goswami J, Jain S, Kochar DK.

Diabetes Res Clin Pract. 2009 Mar;83(3):371-8.

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[Immunopathogenesis and treatment of the myelopathy associated to the HTLV-I virus]

Carod-Artal FJ.

Rev Neurol. 2009 Feb 1-15;48(3):147-55. Review. Spanish.

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Bone metabolism alteration on antiepileptic drug therapy.

Krishnamoorthy G, Karande S, Ahire N, Mathew L, Kulkarni M.

Indian J Pediatr. 2009 Apr;76(4):377-83. Epub 2009 Feb 10.

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[Do results of the recent clinical trials change the place of valproate in treatment of epilepsy?]

Bosak M.

Przegl Lek. 2008;65(11):807-9. Review. Polish.

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[Endocrine effects of antiepileptic drugs]

Leśkiewicz M, Budziszewska B, Lasoń W.

Przegl Lek. 2008;65(11):795-8. Review. Polish.

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[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice]

Chwalczuk K, Rubaj A, Swiader M, Czuczwar SJ.

Przegl Lek. 2008;65(11):759-63. Polish.

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Sodium valproate as a cause of recurrent transudative pleural effusion: a case report.

Tryfon S, Saroglou M, Kazanas K, Mermigkis C, Psathakis K, Galanis N.

J Med Case Reports. 2009 Feb 9;3:51.

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Monitoring the safety of antiepileptic medication in a child with Brugada syndrome.

Van Gorp V, Danschutter D, Huyghens L, Hachimi-Idrissi S, Sarkozy A, Chierchia GB, Henkens S, Brugada P.

Int J Cardiol. 2009 Feb 6. [Epub ahead of print]

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A case of fetal valproate syndrome with new features expanding the phenotype.

Seidahmed MZ, Miqdad AM, Al-Dohami HS, Shareefi OM.

Saudi Med J. 2009 Feb;30(2):288-91.

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A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence.

Kemp DE, Gao K, Ganocy SJ, Elhaj O, Bilali SR, Conroy C, Findling RL, Calabrese JR.

J Clin Psychiatry. 2009 Jan;70(1):113-21. Epub 2008 Dec 30.

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Infantile Spasms and Down syndrome: A New Animal Model.

Cortez MA, Shen L, Wu Y, Aleem IS, Trepanier CH, Sadeghnia HR, Ashraf A, Kanawaty A, Liu CC, Stewart L, Snead OC 3rd.

Pediatr Res. 2009 Jan 28. [Epub ahead of print]

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Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors.

Xiao X, Ning L, Chen H.

Mol Cancer Ther. 2009 Feb;8(2):350-6. Epub 2009 Feb 3.

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Valproate-induced insulin resistance and obesity in children.

Verrotti A, la Torre R, Trotta D, Mohn A, Chiarelli F.

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Lithium increases synapse formation between hippocampal neurons by depleting phosphoinositides.

Kim HJ, Thayer SA.

Mol Pharmacol. 2009 May;75(5):1021-30. Epub 2009 Feb 2.

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Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population.

Gavin DP, Kartan S, Chase K, Jayaraman S, Sharma RP.

J Psychiatr Res. 2009 Jun;43(9):870-6. Epub 2009 Feb 1.

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Nachtkamp K, Kündgen A, Strupp C, Giagounidis A, Kobbe G, Gattermann N, Haas R, Germing U.

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Nonalcoholic fatty liver disease during valproate therapy.

Verrotti A, Di Marco G, la Torre R, Pelliccia P, Chiarelli F.

Eur J Pediatr. 2009 Jan 30. [Epub ahead of print]

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Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.

Garcia M, Huppertz HJ, Ziyeh S, Buechert M, Schumacher M, Mader I.

Epilepsia. 2009 Mar;50(3):486-92. Epub 2008 Oct 3.

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Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy.

Gurpur PB, Liu J, Burkin DJ, Kaufman SJ.

Am J Pathol. 2009 Mar;174(3):999-1008. Epub 2009 Jan 29.

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Mizoi Y, Sumita N, Yamamoto T, Komori T, Tamura N, Shimazu K.

Brain Nerve. 2009 Jan;61(1):77-81. Japanese.

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[Inhibitory effect of valproic acid on cell cycle of Kasumi-1 cell line and its mechanism]

Zhao L, Zhang ZH, Zhu CM.

Zhonghua Xue Ye Xue Za Zhi. 2008 Dec;29(12):802-5. Chinese.

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[Valproate treatment during pregnancy: description of four cases with foetal valproate syndrome]

Sabers A, Larsen K, Blichfeldt S, Sahlholdt L, Rasmussen JO.

Ugeskr Laeger. 2009 Jan 19;171(4):221-5. Danish.

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Serum and muscle carnitine levels in epileptic children receiving sodium valproate.

Anil M, Helvaci M, Ozbal E, Kalenderer O, Anil AB, Dilek M.

J Child Neurol. 2009 Jan;24(1):80-6.

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Persistence with migraine prophylactic treatment and acute migraine medication utilization in the managed care setting.

Yaldo AZ, Wertz DA, Rupnow MF, Quimbo RM.

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A method to rank order water soluble compounds according to their toxicity using Caenorhabditis elegans, a Complex Object Parametric Analyzer and Sorter, and axenic liquid media.

Sprando RL, Olejnik N, Cinar HN, Ferguson M.

Food Chem Toxicol. 2009 Apr;47(4):722-8. Epub 2009 Jan 8.

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Aripiprazole-induced sialorrhea.

Praharaj SK, Jana AK, Sinha VK.

Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):384-5. Epub 2009 Jan 3. No abstract available.

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Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.

Shen S, Sandoval J, Swiss VA, Li J, Dupree J, Franklin RJ, Casaccia-Bonnefil P.

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Olanzapine in long-term treatment for bipolar disorder.

Cipriani A, Rendell JM, Geddes J.

Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004367. Review.

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Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.

Ecke I, Petry F, Rosenberger A, Tauber S, Mönkemeyer S, Hess I, Dullin C, Kimmina S, Pirngruber J, Johnsen SA, Uhmann A, Nitzki F, Wojnowski L, Schulz-Schaeffer W, Witt O, Hahn H.

Cancer Res. 2009 Feb 1;69(3):887-95. Epub 2009 Jan 20.

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Improvement of obsessive-compulsive disorder with divalproex and lamotrigine in two patients with bipolar II disorder.

Bisol LW, Lara DR.

Pharmacopsychiatry. 2009 Jan;42(1):37-9. Epub 2009 Jan 19. No abstract available.

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Medications as risk factors of Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a pooled analysis.

Levi N, Bastuji-Garin S, Mockenhaupt M, Roujeau JC, Flahault A, Kelly JP, Martin E, Kaufman DW, Maison P.

Pediatrics. 2009 Feb;123(2):e297-304. Epub 2009 Jan 19.

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Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate.

Poggi A, Catellani S, Garuti A, Pierri I, Gobbi M, Zocchi MR.

Leukemia. 2009 Apr;23(4):641-8. Epub 2009 Jan 8.

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[Evaluation of efficacy and safety of adjuvant analgesics for peripheral neuropathy induced by cancer chemotherapy in digestive cancer patients-a pilot study]

Yano T, Yamane H, Fukuoka R, Ninomiya T, Umemura S, Suzuki S, Saeki H, Hanaoka T, Katou T, Itoh K, Fujita T, Kamei H.

Gan To Kagaku Ryoho. 2009 Jan;36(1):83-7. Japanese.

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Effects of the histone deacetylase inhibitor valproic acid on the sensitivity of anaplastic thyroid cancer cell lines to imatinib.

Catalano MG, Pugliese M, Poli R, Bosco O, Bertieri R, Fortunati N, Boccuzzi G.

Oncol Rep. 2009 Feb;21(2):515-21.

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Myoclonus in fraternal twin toddlers: A French family with a novel mutation in the SGCE gene.

Thümmler S, Giuliano F, Pincemaille O, Saugier-Veber P, Perelman S.

Eur J Paediatr Neurol. 2009 Jan 13. [Epub ahead of print]

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